Compound Detail
CHEMBL304205
ACRIDAN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL304205 |
| Name | ACRIDAN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HJCUTNIGJHJGCF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
181.2
MW (Da)
3.33
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| U-937 CHEMBL612794 | IC50 | 6.17 | 6.17 | 680.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| Cyclooxygenase CHEMBL2095157 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| U-937 | IC50 | = | 680.0 | nM | 6.17 | Cytotoxicity in UV-irradiated human U937 cells exposed to photosensitizer for 2 ... | 24900465 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 1600.0 | nM | 5.8 | In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1)... | 2113951 |
| Cyclooxygenase | IC50 | = | 1900.0 | nM | 5.72 | In vitro inhibition of Prostaglandin G/H synthase pathway in rat basophilic leuk... | 2113951 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2113951 | 10.1021/jm00169a035 | Cyclooxygenase | 1 |
| 2113951 | 10.1021/jm00169a035 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| 24900465 | 10.1021/ml200266v | U-937 | 1 |
Data from ChEMBL 36 via Core Engine