Cyclooxygenase · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P35355. Use UniProt P35355 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35355 as the stable identity anchor, then attach disease evidence before program review.
Prostaglandin G/H synthase 2
Review this target as Cyclooxygenase, mapped to UniProt P35355. ChEMBL maps the protein component as Prostaglandin G/H synthase 2. Sequence length is 604 aa.
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This review treats Cyclooxygenase as ChEMBL target CHEMBL2095157, mapped to UniProt P35355. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclooxygenase |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P35355 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 2 |
| UniProt Accession | P35355 |
| Component Type | Protein |
| Sequence Length | 604 aa |
Prostaglandin G/H synthase 2
Review this target as Cyclooxygenase, mapped to UniProt P35355. ChEMBL maps the protein component as Prostaglandin G/H synthase 2. Sequence length is 604 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL305076 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL60496 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL64507 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL6 | 8.54 | IC50 | 2.9 | Approved |
| CHEMBL341135 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL126669 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL128000 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL64813 | 8.21 | IC50 | 6.2 | Preclinical |
| CHEMBL60725 | 8.04 | IC50 | 9.1 | Preclinical |
| CHEMBL291543 | 8.02 | IC50 | 9.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 33 | 234 | 5.7 |
| protein format | 32 | 48 | 5.8 |
| assay format | 26 | 54 | 5.9 |
| tissue-based format | 1 | 1 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 9 | 57 | 5.3 |
| cell-based format | 5 | 26 | 7.1 |
| organism-based format | 5 | 0 | — |
| tissue-based format | 1 | 0 | — |