Compound Detail
CHEMBL509
MECLOFENAMIC ACID 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL509 |
| Name | MECLOFENAMIC ACID |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | SBDNJUWAMKYJOX-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
20
Targets
47
Activities
4
Assay Types
3
PK Parameters
20
Publications
9
Known Names
3
Indications
Molecular Properties
296.1
MW (Da)
4.74
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1980 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Arthralgia Myalgia Rheumatic Diseases
ATC Classification
M01AG04
meclofenamic acid
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M02AA18
meclofenamic acid
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Activity Summary
IC50 35 meas. best 7.96
Kd 5 meas. best 6.32
Ki 5 meas. best 6.59
EC50 2 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 7.96 | 7.1733 | 11.0 | 3 |
| Prostaglandin G/H synthase 1 CHEMBL2949 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Cyclooxygenase CHEMBL2095157 | IC50 | 7.0 | 7.0 | 100.0 | 4 |
| Prostaglandin G/H synthase 2 CHEMBL4321 | IC50 | 6.7 | 6.55 | 200.0 | 2 |
| Prostaglandin G/H synthase 1 CHEMBL221 | IC50 | 6.69 | 6.675 | 203.0 | 2 |
| Fatty acid-binding protein, liver CHEMBL5738 | Ki | 6.59 | 6.505 | 256.0 | 2 |
| Transthyretin CHEMBL3194 | Kd | 6.32 | 6.32 | 480.0 | 1 |
| Transthyretin CHEMBL3194 | IC50 | 6.3 | 5.3 | 504.0 | 2 |
| Aldo-keto reductase family 1 member C3 CHEMBL4681 | IC50 | 6.29 | 6.2767 | 512.0 | 3 |
| Aldo-keto reductase family 1 member C1 CHEMBL5905 | IC50 | 6.13 | 5.71 | 740.0 | 3 |
| Staphylococcus aureus CHEMBL352 | IC50 | 6.06 | 6.06 | 877.0 | 1 |
| Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha CHEMBL3885613 | EC50 | 6.05 | 6.05 | 900.0 | 1 |
| Mitogen-activated protein kinase 1 CHEMBL4040 | IC50 | 5.5 | 5.5 | 3144.0 | 1 |
| Nuclear receptor subfamily 4immunitygroup A member 1 CHEMBL1293229 | EC50 | 5.33 | 5.33 | 4700.0 | 1 |
| N6-adenosine-methyltransferase catalytic subunit CHEMBL4739695 | IC50 | 5.1 | 5.1 | 8000.0 | 1 |
| Alpha-ketoglutarate-dependent dioxygenase FTO CHEMBL2331065 | IC50 | 5.1 | 4.9867 | 7940.0 | 3 |
| Aldo-keto reductase family 1 member C2 CHEMBL5847 | IC50 | 5.06 | 5.06 | 8740.0 | 2 |
| Fatty acid-binding protein, intestinal CHEMBL4879 | Ki | 5.05 | 5.05 | 8900.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 4.62 | 4.62 | 24000.0 | 4 |
| Bile salt export pump CHEMBL6020 | IC50 | 4.57 | 4.57 | 27240.0 | 1 |
| Replicase polyprotein 1ab CHEMBL4523582 | Ki | 4.3 | 4.3 | 50000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 28.1 | hr | - |
| T1/2 | 1.5 | hr | Mus musculus |
| T1/2 | 1.5 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine