Assay Detail
Binding
CHEMBL4265759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.88 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290064 | — | — | 1 | 6.80 |
| CHEMBL4282842 | — | — | 1 | 6.78 |
| CHEMBL4279383 | — | — | 1 | 6.67 |
| CHEMBL4293881 | — | — | 1 | 6.64 |
| CHEMBL4291554 | — | — | 1 | 6.62 |
| CHEMBL4286627 | — | — | 1 | 6.59 |
| CHEMBL4287863 | — | — | 1 | 6.56 |
| CHEMBL4287291 | — | — | 1 | 6.54 |
| CHEMBL4295234 | — | — | 1 | 6.33 |
| CHEMBL4280914 | — | — | 1 | 6.32 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | 6.29 |
| CHEMBL4294478 | — | — | 1 | 6.29 |
| CHEMBL4294539 | — | — | 1 | 6.27 |
| CHEMBL4277845 | — | — | 1 | 6.17 |
| CHEMBL4286233 | — | — | 1 | 6.17 |
| CHEMBL4293449 | — | — | 1 | 6.17 |
| CHEMBL4278318 | — | — | 1 | 6.14 |
| CHEMBL4279326 | — | — | 1 | 6.11 |
| CHEMBL4282145 | — | — | 1 | 5.84 |
| CHEMBL4290009 | — | — | 1 | 5.74 |
| CHEMBL4278250 | — | — | 1 | 5.40 |
| CHEMBL4288500 | — | — | 1 | 5.30 |
| CHEMBL4292750 | — | — | 1 | 5.26 |
| CHEMBL4286167 | — | — | 1 | 5.17 |
| CHEMBL1906786 | — | — | 1 | 5.14 |
| CHEMBL4289340 | — | — | 1 | 5.11 |
| CHEMBL4288958 | — | — | 1 | 4.83 |
| CHEMBL4281053 | — | — | 1 | 4.82 |
| CHEMBL4285575 | — | — | 1 | 4.81 |
| CHEMBL1510262 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290064 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4282842 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4279383 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4293881 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4291554 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL4286627 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL4287863 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL4287291 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4295234 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL4280914 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL4294478 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4294539 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL4293449 | — | IC50 | = | 684.0 | nM | 6.17 |
| CHEMBL4286233 | — | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL4277845 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL4278318 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4279326 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL4282145 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4290009 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4278250 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4288500 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL4292750 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL4286167 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL1906786 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL4289340 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4288958 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4281053 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4285575 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1510262 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL1432310 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4293389 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4286587 | — | IC50 | > | 25000.0 | nM | - |