Aldo-keto reductase family 1 member C3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P42330. Use UniProt P42330 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42330 as the stable identity anchor, then attach disease evidence before program review.
Aldo-keto reductase family 1 member C3
Review this target as Aldo-keto reductase family 1 member C3, mapped to UniProt P42330. Sequence length is 323 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Aldo-keto reductase family 1 member C3 as ChEMBL target CHEMBL4681, mapped to UniProt P42330. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Aldo-keto reductase family 1 member C3 is the right protein anchor across sources, using UniProt P42330 as the stable mapping.
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| Preferred Name | Aldo-keto reductase family 1 member C3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42330 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aldo-keto reductase family 1 member C3 |
| UniProt Accession | P42330 |
| Component Type | Protein |
| Sequence Length | 323 aa |
Aldo-keto reductase family 1 member C3
Review this target as Aldo-keto reductase family 1 member C3, mapped to UniProt P42330. Sequence length is 323 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2413849 | 9.47 | IC50 | 0.34 | Preclinical |
| CHEMBL4110932 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5821749 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5823188 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5830459 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5780480 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL6057463 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL5861450 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL5937799 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL4113242 | 9.1 | IC50 | 0.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 104 | 205 | 6.9 |
| single protein format | 51 | 447 | 6.3 |
| assay format | 28 | 341 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 0 | — |