Assay Detail
Binding
CHEMBL762445
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Inhibition of Prostaglandin G/H synthase mediated PGF2-alpha formation in rat basophilic leukemia (RBL-1) cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.85 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | 7.00 |
| CHEMBL53610 | — | — | 1 | 6.60 |
| CHEMBL298672 | — | — | 1 | 6.57 |
| CHEMBL301586 | — | — | 1 | 6.29 |
| CHEMBL50833 | — | — | 1 | 6.21 |
| CHEMBL54156 | — | — | 1 | 6.16 |
| CHEMBL299794 | — | — | 1 | 6.07 |
| CHEMBL301990 | — | — | 1 | 6.00 |
| CHEMBL417022 | — | — | 1 | 5.77 |
| CHEMBL53532 | — | — | 1 | 5.72 |
| CHEMBL53805 | — | — | 1 | 5.58 |
| CHEMBL297733 | — | — | 1 | 5.21 |
| CHEMBL300637 | — | — | 1 | 5.15 |
| CHEMBL301136 | — | — | 1 | 4.96 |
| CHEMBL298776 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL53610 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL298672 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL301586 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL50833 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL54156 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL299794 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL301990 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL417022 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL53532 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL53805 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL297733 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL300637 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL301136 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL298776 | — | IC50 | = | 30000.0 | nM | 4.52 |