Prostaglandin G/H synthase 1 · SINGLE PROTEIN · Ovis aries
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As of 2026-09-13Protein identity stays anchored to UniProt P05979. Use UniProt P05979 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05979 as the stable identity anchor, then attach disease evidence before program review.
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase 1, mapped to UniProt P05979. Sequence length is 600 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prostaglandin G/H synthase 1 as ChEMBL target CHEMBL2949, mapped to UniProt P05979. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Prostaglandin G/H synthase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Ovis aries |
| UniProt | P05979 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 1 |
| UniProt Accession | P05979 |
| Component Type | Protein |
| Sequence Length | 600 aa |
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase 1, mapped to UniProt P05979. Sequence length is 600 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3774784 | 9.54 | IC50 | 0.29 | Preclinical |
| CHEMBL500387 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL502799 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL503071 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL259972 | 8.85 | IC50 | 1.4 | Approved |
| CHEMBL118 | 8.43 | IC50 | 3.7 | Approved |
| CHEMBL214101 | 8.42 | IC50 | 3.8 | Preclinical |
| CHEMBL6 | 8.4 | IC50 | 4.0 | Approved |
| CHEMBL1224097 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5558069 | 8.4 | IC50 | 4.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 484 | 1,507 | 5.3 |
| tissue-based format | 16 | 28 | 5.5 |
| assay format | 10 | 29 | 5.5 |
| cell-based format | 4 | 0 | — |
| organism-based format | 3 | 10 | 4.2 |
| microsome format | 2 | 3 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 40 | 136 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |