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Evidence Snapshot

Prostaglandin G/H synthase 1

CHEMBL2949 SINGLE PROTEIN Ovis aries
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:29:51Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2949
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prostaglandin G/H synthase 1 as ChEMBL target CHEMBL2949, mapped to UniProt P05979. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prostaglandin G/H synthase 1
SINGLE PROTEIN · Ovis aries
As of 2026-09-13
ChEMBL target ID
CHEMBL2949
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P05979
Prostaglandin G/H synthase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Prostaglandin G/H synthase 1 matters

As of 2026-09-13

Prostaglandin G/H synthase 1 is reviewed as Prostaglandin G/H synthase 1 (UniProt P05979); the current evidence base includes 27 approved drugs, 3997 compounds, and 561 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 27 approved drugs, 3997 compounds, and 561 assays for this target. The dominant activity type is IC50. CHEMBL3774784 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL3774784 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
27 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Prostaglandin G/H synthase 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P05979, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

3997
Total Compounds
561
Total Assays
27
Approved Drugs
IC50: 3414.0, KI: 59.0, KD: 6.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3774784
 9.5 IC50 —
No preferred name
CHEMBL500387
 9.0 IC50 —
No preferred name
CHEMBL502799
 9.0 IC50 —
No preferred name
CHEMBL503071
 9.0 IC50 —
No preferred name
CHEMBL259972
 8.8 IC50 Approved

Approved Drugs

Structure Compound First Approval
MELOXICAM
CHEMBL599
 2000
CELECOXIB
CHEMBL118
 1998
MOFEZOLAC
CHEMBL259972
 1994
DICLOFENAC
CHEMBL139
 1988
DICLOFENAC SODIUM
CHEMBL1034
 1988
FLURBIPROFEN
CHEMBL563
 1986
KETOPROFEN
CHEMBL571
 1986
MECLOFENAMIC ACID
CHEMBL509
 1980
NAPROXEN
CHEMBL154
 1976
INDOMETHACIN
CHEMBL6
 1965
THALIDOMIDE
CHEMBL468
 1956
ASPIRIN
CHEMBL25
 1950
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:29:51Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2949