Assay Detail
Binding
CHEMBL3602658
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Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.52 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 7.16 |
| CHEMBL457 | GEMFIBROZIL | 4.0 | 1 | 7.00 |
| CHEMBL121626 | TOLFENAMIC ACID | 2.0 | 1 | 6.82 |
| CHEMBL28 | APIGENIN | — | 1 | 6.60 |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 1 | 6.58 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | 6.32 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 6.24 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 6.00 |
| CHEMBL93645 | ACECLOFENAC | 2.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | Kd | = | 70.0 | nM | 7.16 |
| CHEMBL457 | GEMFIBROZIL | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL121626 | TOLFENAMIC ACID | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL28 | APIGENIN | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL63323 | NIFLUMIC ACID | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL509 | MECLOFENAMIC ACID | Kd | = | 480.0 | nM | 6.32 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 580.0 | nM | 6.24 |
| CHEMBL139 | DICLOFENAC | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL93645 | ACECLOFENAC | Kd | = | 1200.0 | nM | 5.92 |