Compound Detail
CHEMBL457
GEMFIBROZIL 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL457 |
| Name | GEMFIBROZIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HEMJJKBWTPKOJG-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
11
Targets
29
Activities
4
Assay Types
30
PK Parameters
20
Publications
6
Known Names
15
Indications
1
Mechanisms
Molecular Properties
250.3
MW (Da)
3.57
ALogP
2
HBA
1
HBD
46.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1981 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Peroxisome proliferator-activated receptor alpha agonist | AGONIST | Peroxisome proliferator-activated receptor alpha | ✓ | ✓ |
Indications
Abdominal Pain Cardiovascular Diseases Coronary Disease Alcoholism Myocardial Ischemia Parkinson Disease Smoking Cessation Tobacco Use Disorder Anemia Diabetes Mellitus, Type 2 HIV Infections Hypertriglyceridemia Multiple Sclerosis Neoplasms Alzheimer Disease
ATC Classification
C10AB04
gemfibrozil
Level 1: CARDIOVASCULAR SYSTEM
Level 2: LIPID MODIFYING AGENTS
Activity Summary
IC50 14 meas. best 5.39
EC50 11 meas. best 4.93
Ki 3 meas. best 5.73
Kd 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transthyretin CHEMBL3194 | Kd | 7.0 | 7.0 | 100.0 | 1 |
| Fatty acid-binding protein, liver CHEMBL5738 | Ki | 5.73 | 5.73 | 1860.0 | 1 |
| Solute carrier organic anion transporter family member 1B1 CHEMBL1697668 | IC50 | 5.39 | 4.9233 | 4073.8 | 3 |
| Cytochrome P450 2C8 CHEMBL3721 | IC50 | 5.39 | 4.4767 | 4100.0 | 3 |
| Solute carrier organic anion transporter family member 1B3 CHEMBL1743121 | IC50 | 5.15 | 5.15 | 7079.5 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 CHEMBL1795168 | Ki | 5.14 | 5.14 | 7291.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 5.02 | 5.02 | 9600.0 | 1 |
| Peroxisome proliferator-activated receptor alpha CHEMBL239 | EC50 | 4.93 | 4.4633 | 11800.0 | 3 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 4.17 | 4.17 | 68400.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.16 | 4.16 | 69000.0 | 1 |
| Bovine viral diarrhea virus 1 CHEMBL612571 | EC50 | 4.05 | 4.05 | 90000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.09 | mL.min-1.kg-1 | Homo sapiens |
| CL | 29.51 | mL.min-1.g-1 | Homo sapiens |
| CL | 66.07 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 150.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | - | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 17.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 17.5 | mL.min-1.g-1 | Homo sapiens |
| CL | - | - | Homo sapiens |
| CL | 1.73 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.93 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.78 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.02 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.824 | mL.min-1.g-1 | Homo sapiens |
| CL | 24.4 | mL.min-1.g-1 | Homo sapiens |
| CL | 73.6 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.492 | mL.min-1.g-1 | Homo sapiens |
| CL | 3.39 | mL.min-1.g-1 | Homo sapiens |
| CL | 10.4 | mL.min-1.g-1 | Homo sapiens |
| CL | 40.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 23.9 | mL.min-1.g-1 | Homo sapiens |
| CL | 1910.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 265.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 1840.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 259.0 | mL.min-1.g-1 | Homo sapiens |
| F | 80.0 | % | Homo sapiens |
| F | 100.0 | % | Homo sapiens |
| Fu | 0.97 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine