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Target Snapshot

CHEMBL1697668 Target Snapshot

Solute carrier organic anion transporter family member 1B1 · SINGLE PROTEIN · Homo sapiens

2,215Compounds
231Assays
64Approved Drugs
301.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9Y6L6. Use UniProt Q9Y6L6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y6L6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier organic anion transporter family member 1B1 as ChEMBL target CHEMBL1697668, mapped to UniProt Q9Y6L6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier organic anion transporter family member 1B1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1697668
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9Y6L6
Solute carrier organic anion transporter family member 1B1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier organic anion transporter family member 1B1 is the right protein anchor across sources, using UniProt Q9Y6L6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier organic anion transporter family member 1B1
UniProt AccessionQ9Y6L6
Component TypeProtein
Sequence Length691 aa

Solute carrier organic anion transporter family member 1B1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Solute carrier organic anion transporter family member 1B1, mapped to UniProt Q9Y6L6. Sequence length is 691 aa.

Mapped IDQ9Y6L6
Review nameSolute carrier organic anion transporter family member 1B1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

64
Approved
9
Phase III
11
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50201.0
KI92.0
EC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4637446 8.96 EC50 1.1 Preclinical
CHEMBL4636474 8.77 EC50 1.7 Preclinical
CHEMBL4633668 8.35 EC50 4.5 Preclinical
CHEMBL453904 7.36 Ki 44.0 Preclinical
CHEMBL494753 7.34 Ki 45.8 Approved
CHEMBL453904 7.3 IC50 50.0 Preclinical
CHEMBL1491099 7.22 Ki 60.0 Preclinical
CHEMBL4209316 7.18 IC50 66.0 Preclinical
CHEMBL1328088 7.1 Ki 80.0 Preclinical
CHEMBL5077187 7.0 IC50 100.0 Preclinical
Distribution

pChEMBL Value Distribution

44
5.0
94
5.5
63
6.0
18
6.5
7
7.0
0
7.5
1
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RIFAMYCIN
CHEMBL437765
Approved 2018
OLMESARTAN MEDOXOMIL
CHEMBL1200692
Approved 2002
CANDESARTAN CILEXETIL
CHEMBL1014
Approved 1998
ATORVASTATIN CALCIUM
CHEMBL393220
Approved 1996
ATORVASTATIN
CHEMBL1487
Approved 1996
RITONAVIR
CHEMBL163
Approved 1996
LOSARTAN
CHEMBL191
Approved 1995
PACLITAXEL
CHEMBL428647
Approved 1992
CYCLOSPORINE
CHEMBL160
Approved 1983
BETA CAROTENE
CHEMBL1293
Approved 1982
ESTRONE SULFURIC ACID
CHEMBL494753
Approved 1977
RIFAMPIN
CHEMBL374478
Approved 1971
DICLOXACILLIN SODIUM
CHEMBL1200701
Approved 1968
HYDROXYZINE PAMOATE
CHEMBL1200467
Approved 1959
SULFASALAZINE
CHEMBL421
Approved 1950
Assay Landscape

Assay Landscape

232
Total Assays
131
Tested Compounds
4
Assay Types
Functional — 102 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 101 16 5.9
assay format 1 1 6.4
ADME — 82 assays, 131 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 60 113 5.8
single protein format 21 18 5.6
assay format 1 0
Binding — 47 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 32 10 5.0
cell-based format 15 11 5.7
Toxicity — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 1 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine