Compound Detail

CHEMBL1200467

HYDROXYZINE PAMOATE

💊 Approved Drug

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💊 Approved Drug

O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1200467
Name	HYDROXYZINE PAMOATE
Phase	Approved
Structure Type	MOL
InChI Key	ASDOKGIIKXGMNB-UHFFFAOYSA-N
Therapeutic	✓ Yes
Parent Compound	CHEMBL896
Active Moiety	CHEMBL896

Known Names

"hy-pam ""25""" Hy-pam Hy-pam "25" Hydroxyzine embonate Hydroxyzine pamoate NSC-757063 Vistaril

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

374.9

MW (Da)

3.06

ALogP

HBA

HBD

35.9

PSA (Å²)

0.72

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	1959
Availability	Prescription
Chirality	Racemic

Routes of Administration

Oral

Extended Properties

Molecular Formula	C44H43ClN2O8
MW	763.29
Aromatic Rings	2
Heavy Atoms	26
NP-Likeness	-1.17

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Histamine H1 receptor antagonist	ANTAGONIST	Histamine H1 receptor	✓	✓

Indications

Anxiety Neurotic Disorders Pruritus Skin Diseases Urticaria

Activity Summary

IC50 3 meas. best 6.09

Ki 2 meas. best 6.35

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Solute carrier organic anion transporter family member 1B1 CHEMBL1697668	Ki	6.35	6.35	450.0	1
Solute carrier organic anion transporter family member 1B1 CHEMBL1697668	IC50	6.09	6.09	812.8	1
Solute carrier organic anion transporter family member 1B3 CHEMBL1743121	Ki	6.03	6.03	940.0	1
Solute carrier organic anion transporter family member 1B3 CHEMBL1743121	IC50	5.91	5.91	1230.3	1
Envelope glycoprotein gp160 CHEMBL1293311	IC50	5.2	5.2	6310.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Solute carrier organic anion transporter family member 1B1	Ki	=	450.0	nM	6.35	Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells	23571415
Solute carrier organic anion transporter family member 1B1	IC50	=	812.83	nM	6.09	pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO ce...	23571415
Solute carrier organic anion transporter family member 1B3	Ki	=	940.0	nM	6.03	Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells	23571415
Solute carrier organic anion transporter family member 1B3	IC50	=	1230.27	nM	5.91	pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO ce...	23571415
Envelope glycoprotein gp160	IC50	=	6310.0	nM	5.2	PUBCHEM_BIOASSAY: uHTS fluorescence assay for the identification of Human Immuno...	-

Literature References

PubMed	DOI	Target Context	# Activities
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B3	3
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B1	3
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
-	10.21203/rs.3.rs-23951/v1	SARS-CoV-2	1
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	1
-	10.6019/CHEMBL4513141	Candida albicans	1
-	10.6019/CHEMBL4513141	Cryptococcus neoformans	1
-	10.6019/CHEMBL4513141	Escherichia coli	1
-	10.6019/CHEMBL4513141	Klebsiella pneumoniae	1
-	10.6019/CHEMBL4513141	Pseudomonas aeruginosa	1
-	10.6019/CHEMBL4513141	Acinetobacter baumannii	1
-	10.6019/CHEMBL4513141	Staphylococcus aureus	1

Data from ChEMBL 36 via Core Engine