Assay Detail
Binding
CHEMBL5032690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactivation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Evaluation of PPARδ Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.18 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.84 |
| CHEMBL5080884 | — | — | 1 | 5.89 |
| CHEMBL205434 | — | — | 1 | 5.28 |
| CHEMBL38508 | — | — | 1 | 5.02 |
| CHEMBL5080057 | — | — | 1 | 4.88 |
| CHEMBL5071965 | — | — | 1 | 4.77 |
| CHEMBL5076771 | — | — | 1 | 4.61 |
| CHEMBL457 | GEMFIBROZIL | 4.0 | 1 | 4.17 |
| CHEMBL5081804 | — | — | 1 | - |
| CHEMBL5088887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL5080884 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL205434 | — | EC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL38508 | — | EC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL5080057 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5071965 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5076771 | — | EC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL457 | GEMFIBROZIL | EC50 | = | 68400.0 | nM | 4.17 |
| CHEMBL5081804 | — | EC50 | - | — | - | |
| CHEMBL5088887 | — | EC50 | - | — | - |