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Compound Detail

CHEMBL5071965

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Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CSc1ccc(/C=C/C(=O)O)cc1

Basic Information

ChEMBL ID CHEMBL5071965
Phase Preclinical
Structure Type MOL
InChI Key QZSNOYWWSMIMDW-NYYWCZLTSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

435.5
MW (Da)
6.53
ALogP
4
HBA
1
HBD
50.2
PSA (Ų)
0.35
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H16F3NO2S2
MW 435.49
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -1.24

Activity Summary

EC50 3 meas. best 6.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 6.27 6.27 535.0 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 4.77 4.77 17000.0 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 4.75 4.75 17700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33988379 10.1021/acs.jmedchem.1c00560 Mesenchymal stem cells 4
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor alpha 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor delta 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor gamma 2
33988379 10.1021/acs.jmedchem.1c00560 PPAR delta/gamma 1

Data from ChEMBL 36 via Core Engine