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Compound Detail

CHEMBL205434

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Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CNc1ccc(/C=C/C(=O)O)cc1

Basic Information

ChEMBL ID CHEMBL205434
Phase Preclinical
Structure Type MOL
InChI Key AKPCUYWXGDJENF-NYYWCZLTSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

418.4
MW (Da)
5.85
ALogP
4
HBA
2
HBD
62.2
PSA (Ų)
0.49
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H17F3N2O2S
MW 418.44
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -1.29

Activity Summary

EC50 4 meas. best 7.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Free fatty acid receptor 1
CHEMBL4422
EC50 7.44 7.44 36.3 1
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 5.91 5.91 1220.0 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 5.28 5.28 5280.0 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 5.22 5.22 6010.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33988379 10.1021/acs.jmedchem.1c00560 Mesenchymal stem cells 6
16439116 10.1016/j.bmcl.2006.01.007 Free fatty acid receptor 1 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor alpha 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor delta 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor gamma 2
33988379 10.1021/acs.jmedchem.1c00560 PPAR delta/gamma 1

Data from ChEMBL 36 via Core Engine