Assay Detail
Functional
CHEMBL861844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency at human GPR40 expressed in CHO cells
41
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of small molecule GPR40 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 7.26 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382381 | — | — | 2 | 8.61 |
| CHEMBL382831 | — | — | 1 | 8.35 |
| CHEMBL382915 | — | — | 1 | 8.16 |
| CHEMBL205433 | — | — | 1 | 8.04 |
| CHEMBL380884 | — | — | 2 | 7.96 |
| CHEMBL207753 | — | — | 2 | 7.91 |
| CHEMBL203126 | — | — | 1 | 7.90 |
| CHEMBL381958 | — | — | 1 | 7.89 |
| CHEMBL203297 | — | — | 1 | 7.83 |
| CHEMBL205434 | — | — | 1 | 7.44 |
| CHEMBL204671 | — | — | 1 | 7.40 |
| CHEMBL208175 | — | — | 1 | 7.31 |
| CHEMBL203334 | — | — | 1 | 7.29 |
| CHEMBL208783 | — | — | 1 | 7.27 |
| CHEMBL378275 | — | — | 1 | 7.23 |
| CHEMBL207881 | GW9508 | — | 1 | 7.19 |
| CHEMBL202835 | — | — | 1 | 7.18 |
| CHEMBL204630 | — | — | 1 | 7.17 |
| CHEMBL205263 | — | — | 1 | 7.00 |
| CHEMBL203520 | — | — | 1 | 7.00 |
| CHEMBL382341 | — | — | 1 | 6.94 |
| CHEMBL380719 | — | — | 1 | 6.90 |
| CHEMBL205960 | — | — | 1 | 6.84 |
| CHEMBL206779 | — | — | 1 | 6.76 |
| CHEMBL382884 | — | — | 1 | 6.69 |
| CHEMBL206881 | — | — | 1 | 6.54 |
| CHEMBL206942 | — | — | 1 | 6.52 |
| CHEMBL206572 | — | — | 1 | 6.49 |
| CHEMBL380504 | — | — | 1 | 6.45 |
| CHEMBL204455 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382381 | — | EC50 | = | 2.455 | nM | 8.61 |
| CHEMBL382831 | — | EC50 | = | 4.467 | nM | 8.35 |
| CHEMBL382381 | — | EC50 | = | 4.898 | nM | 8.31 |
| CHEMBL382915 | — | EC50 | = | 6.918 | nM | 8.16 |
| CHEMBL205433 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL380884 | — | EC50 | = | 10.96 | nM | 7.96 |
| CHEMBL207753 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL203126 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL381958 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL207753 | — | EC50 | = | 13.49 | nM | 7.87 |
| CHEMBL380884 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL203297 | — | EC50 | = | 14.79 | nM | 7.83 |
| CHEMBL205434 | — | EC50 | = | 36.31 | nM | 7.44 |
| CHEMBL204671 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL208175 | — | EC50 | = | 48.98 | nM | 7.31 |
| CHEMBL203334 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL208783 | — | EC50 | = | 53.7 | nM | 7.27 |
| CHEMBL378275 | — | EC50 | = | 58.88 | nM | 7.23 |
| CHEMBL207881 | GW9508 | EC50 | = | 64.57 | nM | 7.19 |
| CHEMBL202835 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL204630 | — | EC50 | = | 67.61 | nM | 7.17 |
| CHEMBL205263 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL203520 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL382341 | — | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL380719 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL205960 | — | EC50 | = | 144.54 | nM | 6.84 |
| CHEMBL206779 | — | EC50 | = | 173.78 | nM | 6.76 |
| CHEMBL382884 | — | EC50 | = | 204.17 | nM | 6.69 |
| CHEMBL206881 | — | EC50 | = | 288.4 | nM | 6.54 |
| CHEMBL206942 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL206572 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL380504 | — | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL204455 | — | EC50 | = | 562.34 | nM | 6.25 |
| CHEMBL205090 | — | EC50 | = | 1122.02 | nM | 5.95 |
| CHEMBL206880 | — | EC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL383445 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL206494 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL206972 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL438070 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL208130 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL380517 | — | EC50 | < | 10000.0 | nM | - |