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Compound Detail

CHEMBL5080057

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Cc1nc(-c2ccc(C(F)(F)F)c(F)c2)sc1COc1ccc(/C=C/C(=O)O)cc1

Basic Information

ChEMBL ID CHEMBL5080057
Phase Preclinical
Structure Type MOL
InChI Key ZOFFYJFCUATPDF-RUDMXATFSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

437.4
MW (Da)
5.95
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.38
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H15F4NO3S
MW 437.41
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -1.08

Activity Summary

EC50 3 meas. best 7.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 7.02 7.02 95.9 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 4.88 4.88 13200.0 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 4.29 4.29 51300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33988379 10.1021/acs.jmedchem.1c00560 Mesenchymal stem cells 6
33988379 10.1021/acs.jmedchem.1c00560 ADMET 3
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor alpha 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor delta 2
33988379 10.1021/acs.jmedchem.1c00560 Peroxisome proliferator-activated receptor gamma 2
33988379 10.1021/acs.jmedchem.1c00560 Mus musculus 2
33988379 10.1021/acs.jmedchem.1c00560 No relevant target 1

Data from ChEMBL 36 via Core Engine