Cytochrome P450 2C9 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P11712. Use UniProt P11712 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11712 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2C9
Review this target as Cytochrome P450 2C9, mapped to UniProt P11712. Sequence length is 490 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2C9 as ChEMBL target CHEMBL3397, mapped to UniProt P11712. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 2C9 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11712 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2C9 |
| UniProt Accession | P11712 |
| Component Type | Protein |
| Sequence Length | 490 aa |
Cytochrome P450 2C9
Review this target as Cytochrome P450 2C9, mapped to UniProt P11712. Sequence length is 490 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL16596 | 9.3 | IC50 | 0.5 | Clinical |
| CHEMBL220360 | 9.03 | IC50 | 0.93 | Clinical |
| CHEMBL1825089 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL38958 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL1922663 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL1223034 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL4593464 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL1172346 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5561914 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL4557596 | 8.47 | IC50 | 3.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2,014 | 1,775 | 5.3 |
| microsome format | 614 | 620 | 5.3 |
| assay format | 256 | 239 | 5.3 |
| cell-based format | 136 | 38 | 5.1 |
| tissue-based format | 61 | 58 | 5.7 |
| cell membrane format | 4 | 0 | — |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 32 | 118 | 5.2 |
| assay format | 21 | 70 | 5.0 |
| tissue-based format | 10 | 26 | 5.0 |
| microsome format | 5 | 1 | 5.0 |
| cell-based format | 1 | 50 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| microsome format | 1 | 0 | — |