Compound Detail
CHEMBL1200604
TROPICAMIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1200604 |
| Name | TROPICAMIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | BGDKAVGWHJFAGW-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
7
Targets
13
Activities
2
Assay Types
0
PK Parameters
20
Publications
13
Known Names
6
Indications
1
Mechanisms
Molecular Properties
284.4
MW (Da)
2.21
ALogP
3
HBA
1
HBD
53.4
PSA (Ų)
0.88
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1960 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 antagonist | ANTAGONIST | Muscarinic acetylcholine receptor M3 | ✓ | ✓ |
Indications
Mydriasis Eye Diseases Parkinson Disease Presbyopia Sialorrhea Ocular Hypertension
ATC Classification
S01FA06
tropicamide
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
S01FA56
tropicamide, combinations
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
IC50 8 meas. best 7.6
Ki 5 meas. best 8.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 8.46 | 8.46 | 3.5 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | IC50 | 7.6 | 7.6 | 25.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 7.43 | 7.43 | 37.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 7.19 | 7.19 | 64.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 7.17 | 7.17 | 68.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | IC50 | 7.05 | 7.05 | 89.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 6.98 | 6.98 | 105.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 6.85 | 6.85 | 142.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 6.55 | 6.55 | 281.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| - | 10.6019/CHEMBL5058564 | HEK-293T | 8 |
| - | 10.6019/CHEMBL5058564 | U2OS | 5 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 4 |
| - | 10.6019/CHEMBL5209801 | Apelin receptor | 2 |
| - | 10.6019/CHEMBL5209801 | C5a anaphylatoxin chemotactic receptor 1 | 2 |
| - | 10.6019/CHEMBL5209801 | Free fatty acid receptor 4 | 2 |
| - | 10.6019/CHEMBL5209801 | Glucose-dependent insulinotropic receptor | 2 |
| - | 10.6019/CHEMBL5058564 | Fibroblast | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL5209801 | N-formyl peptide receptor 2 | 2 |
| - | 10.6019/CHEMBL5209801 | Sphingosine 1-phosphate receptor 1 | 2 |
| - | 10.6019/CHEMBL5209801 | Adhesion G-protein coupled receptor F1 | 2 |
| - | 10.6019/CHEMBL5209801 | G-protein coupled receptor 35 | 2 |
| - | 10.6019/CHEMBL5209801 | Type-1 angiotensin II receptor | 2 |
| - | 10.6019/CHEMBL5209801 | Alpha-2A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| - | 10.6019/CHEMBL5209801 | Beta-2 adrenergic receptor | 2 |
| - | 10.6019/CHEMBL5209801 | CX3C chemokine receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine