Assay Detail
Binding
CHEMBL1909172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.33 | 8.95 |
| Ki | 871 | 7.00 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | 4.0 | 2 | 9.62 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 2 | 9.56 |
| CHEMBL517712 | ATROPINE | 4.0 | 2 | 9.36 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 2 | 9.24 |
| CHEMBL1123 | DICYCLOMINE | 4.0 | 2 | 9.03 |
| CHEMBL1490 | TRIHEXYPHENIDYL | 4.0 | 2 | 8.50 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 2 | 8.38 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 2 | 8.27 |
| CHEMBL2107687 | VALETHAMATE BROMIDE | -1.0 | 2 | 8.25 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 2 | 8.14 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 8.08 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 8.02 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 2 | 7.82 |
| CHEMBL1319362 | HOMATROPINE HYDROBROMIDE | -1.0 | 2 | 7.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 7.77 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 7.72 |
| CHEMBL1200604 | TROPICAMIDE | 4.0 | 2 | 7.52 |
| CHEMBL1909073 | PIPERILATE ETHOBROMIDE | — | 2 | 7.48 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 2 | 7.44 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 2 | 7.44 |
| CHEMBL900 | ORPHENADRINE | 4.0 | 2 | 7.43 |
| CHEMBL490 | PAROXETINE | 4.0 | 2 | 7.42 |
| CHEMBL395110 | MEPAZINE | 4.0 | 2 | 7.40 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 7.36 |
| CHEMBL936 | DIPHENIDOL | 4.0 | 2 | 7.28 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | 7.09 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 7.08 |
| CHEMBL564 | PROMAZINE | 4.0 | 2 | 7.06 |
| CHEMBL1172 | DESLORATADINE | 4.0 | 2 | 7.02 |
| CHEMBL1200406 | DIMENHYDRINATE | 4.0 | 2 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | = | 0.239 | nM | 9.62 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 0.272 | nM | 9.56 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.439 | nM | 9.36 |
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 0.574 | nM | 9.24 |
| CHEMBL1123 | DICYCLOMINE | Ki | = | 0.927 | nM | 9.03 |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | = | 1.129 | nM | 8.95 |
| CHEMBL1201203 | BENZTROPINE | IC50 | = | 1.285 | nM | 8.89 |
| CHEMBL517712 | ATROPINE | IC50 | = | 2.071 | nM | 8.68 |
| CHEMBL1231 | OXYBUTYNIN | IC50 | = | 2.71 | nM | 8.57 |
| CHEMBL1490 | TRIHEXYPHENIDYL | Ki | = | 3.151 | nM | 8.50 |
| CHEMBL643 | PROMETHAZINE | Ki | = | 4.149 | nM | 8.38 |
| CHEMBL1123 | DICYCLOMINE | IC50 | = | 4.375 | nM | 8.36 |
| CHEMBL629 | AMITRIPTYLINE | Ki | = | 5.436 | nM | 8.27 |
| CHEMBL2107687 | VALETHAMATE BROMIDE | Ki | = | 5.585 | nM | 8.25 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | Ki | = | 7.297 | nM | 8.14 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 8.253 | nM | 8.08 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 9.655 | nM | 8.02 |
| CHEMBL1628227 | DOXEPIN | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1490 | TRIHEXYPHENIDYL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1319362 | HOMATROPINE HYDROBROMIDE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL643 | PROMETHAZINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2107687 | VALETHAMATE BROMIDE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1200604 | TROPICAMIDE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1909073 | PIPERILATE ETHOBROMIDE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL445 | NORTRIPTYLINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL900 | ORPHENADRINE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL490 | PAROXETINE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL395110 | MEPAZINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL516 | CYPROHEPTADINE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL936 | DIPHENIDOL | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL1628227 | DOXEPIN | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1319362 | HOMATROPINE HYDROBROMIDE | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL715 | OLANZAPINE | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL564 | PROMAZINE | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1200406 | DIMENHYDRINATE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1172 | DESLORATADINE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL21731 | MAPROTILINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL657 | DIPHENHYDRAMINE | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL305660 | EBASTINE | Ki | = | 137.2 | nM | 6.86 |
| CHEMBL1200604 | TROPICAMIDE | IC50 | = | 142.0 | nM | 6.85 |