Review anchor
Muscarinic acetylcholine receptor M3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Muscarinic acetylcholine receptor M3
CHEMBL245
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M3 as ChEMBL target CHEMBL245, mapped to UniProt P20309. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL245
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P20309
Muscarinic acetylcholine receptor M3
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Muscarinic acetylcholine receptor M3 matters
Muscarinic acetylcholine receptor M3 is reviewed as Muscarinic acetylcholine receptor M3 (UniProt P20309); Muscarinic acetylcholine receptor M3 shows approved-linked disease relevance led by chronic obstructive pulmonary disease. 5 more disease programs remain visible in the same review block.; 13 linked drugs keep this evidence frame grounded.; the current evidence base includes 149 approved drugs, 5882 compounds, and 805 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Muscarinic acetylcholine receptor M3
Muscarinic acetylcholine receptor M3 Sequence length is 590 aa.
Review this target as Muscarinic acetylcholine receptor M3, mapped to UniProt P20309. Sequence length is 590 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P20309
Protein
Disease context
chronic obstructive pulmonary disease
Muscarinic acetylcholine receptor M3 shows approved-linked disease relevance led by chronic obstructive pulmonary disease. 5 more disease programs remain visible in the same review block. 13 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include ACLIDINIUM BROMIDE, ASM-024, AZD-9164.
Start review with chronic obstructive pulmonary disease because it currently carries approved-linked support. Linked drugs include ACLIDINIUM BROMIDE, ASM-024, AZD-9164, AZD8683. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target record
Approved-linked
13 linked drugs
Activity base
Portfolio and assay base
ChEMBL currently tracks 149 approved drugs, 5882 compounds, and 805 assays for this target. The dominant activity type is KI. CHEMBL521523 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL521523 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
149 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M3 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P20309, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need to see why chronic obstructive pulmonary disease is currently treated as approved-linked support.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
5882
Total Compounds
805
Total Assays
149
Approved Drugs
IC50: 2024.0, KI: 3486.0, EC50: 260.0, KD: 114.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL521523
|
11.0 | Kd | — |
|
|
No preferred name
CHEMBL5556228
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL1683934
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL3545181
|
11.0 | Ki | Approved |
|
|
No preferred name
CHEMBL5527849
|
11.0 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
XANOMELINE
CHEMBL21536
|
2024 |
|
|
UMECLIDINIUM BROMIDE
CHEMBL523299
|
2013 |
|
|
ACLIDINIUM
CHEMBL1194325
|
2012 |
|
|
ACLIDINIUM BROMIDE
CHEMBL551466
|
2012 |
|
|
TIOTROPIUM
CHEMBL1900528
|
2004 |
|
|
SOLIFENACIN
CHEMBL1734
|
2004 |
|
|
TROSPIUM CHLORIDE
CHEMBL3084748
|
2004 |
|
|
TIOTROPIUM BROMIDE
CHEMBL3545181
|
2004 |
|
|
DARIFENACIN
CHEMBL1346
|
2004 |
|
|
SOLIFENACIN SUCCINATE
CHEMBL1200803
|
2004 |
|
|
DESLORATADINE
CHEMBL1172
|
2001 |
|
|
KETOTIFEN
CHEMBL534
|
1999 |
|
|
KETOTIFEN FUMARATE
CHEMBL1633
|
1999 |
|
|
TOLTERODINE TARTRATE
CHEMBL1722209
|
1998 |
|
|
TOLTERODINE
CHEMBL1382
|
1998 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
EBASTINE
CHEMBL305660
|
1990 |
|
|
CLOZAPINE
CHEMBL42
|
1989 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
ASTEMIZOLE
CHEMBL296419
|
1988 |
|
|
OXICONAZOLE
CHEMBL1262
|
1988 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
IPRATROPIUM
CHEMBL1621597
|
1986 |
|
|
AMIODARONE
CHEMBL633
|
1985 |
|
|
SULCONAZOLE
CHEMBL1221
|
1985 |
|
|
CYCLIZINE
CHEMBL648
|
1982 |
|
|
ECONAZOLE
CHEMBL808
|
1982 |
|
|
GENTIAN VIOLET
CHEMBL64894
|
1982 |
|
|
DEXCHLORPHENIRAMINE
CHEMBL1201353
|
1981 |
|
|
MAPROTILINE
CHEMBL21731
|
1980 |
|
|
AMOXAPINE
CHEMBL1113
|
1980 |
|
|
SCOPOLAMINE
CHEMBL569713
|
1979 |
|
|
SULOCTIDIL
CHEMBL404849
|
1979 |
|
|
CLEMASTINE
CHEMBL1626
|
1977 |
|
|
TAMOXIFEN
CHEMBL83
|
1977 |
|
|
OXYBUTYNIN
CHEMBL1231
|
1975 |
|
|
MICONAZOLE
CHEMBL91
|
1974 |
|
|
PERHEXILINE
CHEMBL75880
|
1974 |
|
|
ACETYLCHOLINE
CHEMBL667
|
1973 |
|
|
ACETYLCHOLINE CHLORIDE
CHEMBL1184
|
1973 |
|
|
CARBACHOL
CHEMBL14
|
1972 |
|
|
DIMENHYDRINATE
CHEMBL1200406
|
1972 |
|
|
DOXEPIN
CHEMBL1628227
|
1969 |
|
|
DIPHENIDOL
CHEMBL936
|
1967 |
|
|
NORTRIPTYLINE
CHEMBL445
|
1964 |
|
|
THIORIDAZINE
CHEMBL479
|
1962 |
|
|
GLYCOPYRRONIUM
CHEMBL1201335
|
1961 |
|
|
AMITRIPTYLINE
CHEMBL629
|
1961 |
|
|
GLYCOPYRRONIUM BROMIDE
CHEMBL1201027
|
1961 |
Source Header