Compound Detail
CHEMBL1201335
GLYCOPYRRONIUM 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1201335 |
| Name | GLYCOPYRRONIUM |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | ANGKOCUUWGHLCE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
4
Activities
2
Assay Types
4
PK Parameters
16
Publications
6
Known Names
4
Indications
Molecular Properties
318.4
MW (Da)
2.46
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1961 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Asthma Hyperhidrosis Pulmonary Disease, Chronic Obstructive Severe Acute Respiratory Syndrome
ATC Classification
D11AA01
glycopyrronium
Level 1: DERMATOLOGICALS
Level 2: OTHER DERMATOLOGICAL PREPARATIONS
Activity Summary
IC50 3 meas. best 9.9
Kd 1 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 9.9 | 9.75 | 0.1 | 2 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 9.8 | 9.8 | 0.2 | 1 |
| Unchecked CHEMBL612545 | Kd | 9.3 | 9.3 | 0.5 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 91.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | IC50 | = | 0.1259 | nM | 9.9 | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 c... | 24144851 |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 0.1585 | nM | 9.8 | Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 c... | 22047691 |
| Muscarinic acetylcholine receptor M3 | IC50 | = | 0.2512 | nM | 9.6 | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 c... | 22047691 |
| Unchecked | Kd | = | 0.5012 | nM | 9.3 | Antagonist potency at M3 receptor in Dunkin Hartley guinea pig trachea assessed ... | 22047691 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3301361 | ADMET | 5 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 26948801 | 10.1016/j.drudis.2016.02.015 | Homo sapiens | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 22047691 | 10.1016/j.bmcl.2011.10.002 | Unchecked | 1 |
| 22047691 | 10.1016/j.bmcl.2011.10.002 | Plasma | 1 |
| 22047691 | 10.1016/j.bmcl.2011.10.002 | Liver microsomes | 1 |
| 22047691 | 10.1016/j.bmcl.2011.10.002 | Muscarinic acetylcholine receptor M2 | 1 |
| 22047691 | 10.1016/j.bmcl.2011.10.002 | Muscarinic acetylcholine receptor M3 | 1 |
| 24144851 | 10.1016/j.bmcl.2013.09.092 | Molecular identity unknown | 1 |
| 24144851 | 10.1016/j.bmcl.2013.09.092 | Liver microsome | 1 |
| 24144851 | 10.1016/j.bmcl.2013.09.092 | Muscarinic acetylcholine receptor M3 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine