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Assay Detail

CHEMBL1924273

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs
ChEMBL ↗
85
Total Activities
85
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M3 (CHEMBL245) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The discovery of AZD9164, a novel muscarinic M3 antagonist.
Mete A, Bowers K, Chevalier E, Donald DK, Edwards H, Escott KJ, Ford R, Grime K, Millichip I, Teobald B, Russell V.
Bioorg Med Chem Lett (2011) 21 : 7440 -7446
PubMed 22047691 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 85 9.28 10.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1924027 — — 1 10.50
CHEMBL1921908 — — 1 10.30
CHEMBL1924040 — — 1 10.30
CHEMBL1921925 — — 1 10.20
CHEMBL1921907 — — 1 10.20
CHEMBL1921935 — — 1 10.20
CHEMBL1921917 — — 1 10.10
CHEMBL1921937 — — 1 10.10
CHEMBL1921945 — — 1 10.00
CHEMBL1922053 — — 1 10.00
CHEMBL1924036 — — 1 10.00
CHEMBL1921946 — — 1 9.90
CHEMBL1924049 — — 1 9.90
CHEMBL1921919 — — 1 9.90
CHEMBL1921941 — — 1 9.90
CHEMBL1921918 — — 1 9.80
CHEMBL1924025 — — 1 9.80
CHEMBL1922051 — — 1 9.80
CHEMBL1921904 AZD-9164 2.0 1 9.80
CHEMBL1922054 — — 1 9.80
CHEMBL1921911 — — 1 9.80
CHEMBL1922050 — — 1 9.70
CHEMBL1921944 — — 1 9.70
CHEMBL1921914 — — 1 9.70
CHEMBL1921943 — — 1 9.70
CHEMBL1921927 — — 1 9.70
CHEMBL1921910 — — 1 9.70
CHEMBL1922055 — — 1 9.70
CHEMBL1921942 — — 1 9.70
CHEMBL1921940 — — 1 9.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1924027 — IC50 = 0.03162 nM 10.50
CHEMBL1921908 — IC50 = 0.05012 nM 10.30
CHEMBL1924040 — IC50 = 0.05012 nM 10.30
CHEMBL1921925 — IC50 = 0.0631 nM 10.20
CHEMBL1921907 — IC50 = 0.0631 nM 10.20
CHEMBL1921935 — IC50 = 0.0631 nM 10.20
CHEMBL1921917 — IC50 = 0.07943 nM 10.10
CHEMBL1921937 — IC50 = 0.07943 nM 10.10
CHEMBL1924036 — IC50 = 0.1 nM 10.00
CHEMBL1921945 — IC50 = 0.1 nM 10.00
CHEMBL1922053 — IC50 = 0.1 nM 10.00
CHEMBL1921941 — IC50 = 0.1259 nM 9.90
CHEMBL1921919 — IC50 = 0.1259 nM 9.90
CHEMBL1924049 — IC50 = 0.1259 nM 9.90
CHEMBL1921946 — IC50 = 0.1259 nM 9.90
CHEMBL1921918 — IC50 = 0.1585 nM 9.80
CHEMBL1921911 — IC50 = 0.1585 nM 9.80
CHEMBL1922054 — IC50 = 0.1585 nM 9.80
CHEMBL1921904 AZD-9164 IC50 = 0.1585 nM 9.80
CHEMBL1922051 — IC50 = 0.1585 nM 9.80
CHEMBL1924025 — IC50 = 0.1585 nM 9.80
CHEMBL1922052 — IC50 = 0.1995 nM 9.70
CHEMBL1921940 — IC50 = 0.1995 nM 9.70
CHEMBL1921942 — IC50 = 0.1995 nM 9.70
CHEMBL1922055 — IC50 = 0.1995 nM 9.70
CHEMBL1921927 — IC50 = 0.1995 nM 9.70
CHEMBL1921943 — IC50 = 0.1995 nM 9.70
CHEMBL1921914 — IC50 = 0.1995 nM 9.70
CHEMBL1921944 — IC50 = 0.1995 nM 9.70
CHEMBL1922050 — IC50 = 0.1995 nM 9.70
CHEMBL1921910 — IC50 = 0.1995 nM 9.70
CHEMBL1201335 GLYCOPYRRONIUM IC50 = 0.2512 nM 9.60
CHEMBL1921928 — IC50 = 0.2512 nM 9.60
CHEMBL1922058 — IC50 = 0.2512 nM 9.60
CHEMBL1924029 — IC50 = 0.2512 nM 9.60
CHEMBL1921921 — IC50 = 0.3162 nM 9.50
CHEMBL1921924 — IC50 = 0.3162 nM 9.50
CHEMBL1922056 — IC50 = 0.3162 nM 9.50
CHEMBL1921932 — IC50 = 0.3162 nM 9.50
CHEMBL1922057 — IC50 = 0.3981 nM 9.40
CHEMBL1921926 — IC50 = 0.3981 nM 9.40
CHEMBL1921939 — IC50 = 0.5012 nM 9.30
CHEMBL1924046 — IC50 = 0.631 nM 9.20
CHEMBL1921929 — IC50 = 0.631 nM 9.20
CHEMBL1921936 — IC50 = 0.631 nM 9.20
CHEMBL1924031 — IC50 = 0.7943 nM 9.10
CHEMBL1924030 — IC50 = 0.7943 nM 9.10
CHEMBL1921938 — IC50 = 0.7943 nM 9.10
CHEMBL1924033 — IC50 = 1.0 nM 9.00
CHEMBL1922049 — IC50 = 1.0 nM 9.00