Assay Detail
Binding
CHEMBL1924274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of AZD9164, a novel muscarinic M3 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 10.00 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 10.20 |
| CHEMBL1201335 | GLYCOPYRRONIUM | 4.0 | 1 | 9.80 |
| CHEMBL551466 | ACLIDINIUM BROMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | IC50 | = | 0.0631 | nM | 10.20 |
| CHEMBL1201335 | GLYCOPYRRONIUM | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL551466 | ACLIDINIUM BROMIDE | IC50 | < | 0.03981 | nM | - |