Review anchor
Muscarinic acetylcholine receptor M2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Muscarinic acetylcholine receptor M2
CHEMBL211
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M2 as ChEMBL target CHEMBL211, mapped to UniProt P08172. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL211
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08172
Muscarinic acetylcholine receptor M2
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Muscarinic acetylcholine receptor M2 matters
Muscarinic acetylcholine receptor M2 is reviewed as Muscarinic acetylcholine receptor M2 (UniProt P08172); Muscarinic acetylcholine receptor M2 shows approved-linked disease relevance led by overactive bladder. 5 more disease programs remain visible in the same review block.; 8 linked drugs keep this evidence frame grounded.; the current evidence base includes 156 approved drugs, 6140 compounds, and 1006 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Muscarinic acetylcholine receptor M2
Muscarinic acetylcholine receptor M2 Sequence length is 466 aa.
Review this target as Muscarinic acetylcholine receptor M2, mapped to UniProt P08172. Sequence length is 466 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P08172
Protein
Disease context
overactive bladder
Muscarinic acetylcholine receptor M2 shows approved-linked disease relevance led by overactive bladder. 5 more disease programs remain visible in the same review block. 8 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include DARIFENACIN HYDROBROMIDE, FESOTERODINE FUMARATE, OXYBUTYNIN.
Start review with overactive bladder because it currently carries approved-linked support. Linked drugs include DARIFENACIN HYDROBROMIDE, FESOTERODINE FUMARATE, OXYBUTYNIN, OXYBUTYNIN CHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target record
Approved-linked
8 linked drugs
Activity base
Portfolio and assay base
ChEMBL currently tracks 156 approved drugs, 6140 compounds, and 1006 assays for this target. The dominant activity type is KI. CHEMBL76164 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL76164 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
156 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M2 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P08172, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need to see why overactive bladder is currently treated as approved-linked support.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
6140
Total Compounds
1006
Total Assays
156
Approved Drugs
IC50: 1540.0, KI: 2972.0, EC50: 386.0, KD: 205.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL76164
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL3545181
|
10.7 | Ki | Approved |
|
|
No preferred name
CHEMBL2114068
|
10.5 | Ki | — |
|
|
No preferred name
CHEMBL164705
|
10.5 | Ki | — |
|
|
No preferred name
CHEMBL328094
|
10.5 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
XANOMELINE
CHEMBL21536
|
2024 |
|
|
REVEFENACIN
CHEMBL3833319
|
2018 |
|
|
UMECLIDINIUM BROMIDE
CHEMBL523299
|
2013 |
|
|
ACLIDINIUM BROMIDE
CHEMBL551466
|
2012 |
|
|
TROSPIUM CHLORIDE
CHEMBL3084748
|
2004 |
|
|
DARIFENACIN
CHEMBL1346
|
2004 |
|
|
TIOTROPIUM BROMIDE
CHEMBL3545181
|
2004 |
|
|
SOLIFENACIN
CHEMBL1734
|
2004 |
|
|
SOLIFENACIN SUCCINATE
CHEMBL1200803
|
2004 |
|
|
DESLORATADINE
CHEMBL1172
|
2001 |
|
|
CEVIMELINE
CHEMBL168815
|
2000 |
|
|
KETOTIFEN FUMARATE
CHEMBL1633
|
1999 |
|
|
KETOTIFEN
CHEMBL534
|
1999 |
|
|
TOLTERODINE
CHEMBL1382
|
1998 |
|
|
TOLTERODINE TARTRATE
CHEMBL1722209
|
1998 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
EBASTINE
CHEMBL305660
|
1990 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
CLOZAPINE
CHEMBL42
|
1989 |
|
|
ASTEMIZOLE
CHEMBL296419
|
1988 |
|
|
MITOXANTRONE
CHEMBL58
|
1987 |
|
|
IPRATROPIUM
CHEMBL1621597
|
1986 |
|
|
METHACHOLINE
CHEMBL978
|
1986 |
|
|
PENTAMIDINE
CHEMBL55
|
1984 |
|
|
GENTIAN VIOLET
CHEMBL64894
|
1982 |
|
|
GALLAMINE TRIETHIODIDE
CHEMBL1200993
|
1982 |
|
|
CYCLIZINE
CHEMBL648
|
1982 |
|
|
AMOXAPINE
CHEMBL1113
|
1980 |
|
|
MAPROTILINE
CHEMBL21731
|
1980 |
|
|
SCOPOLAMINE
CHEMBL569713
|
1979 |
|
|
CLEMASTINE
CHEMBL1626
|
1977 |
|
|
OXYBUTYNIN
CHEMBL1231
|
1975 |
|
|
PILOCARPINE
CHEMBL550
|
1974 |
|
|
ACETYLCHOLINE
CHEMBL667
|
1973 |
|
|
DIMENHYDRINATE
CHEMBL1200406
|
1972 |
|
|
CARBACHOL
CHEMBL14
|
1972 |
|
|
DOXEPIN
CHEMBL1628227
|
1969 |
|
|
DIPHENIDOL
CHEMBL936
|
1967 |
|
|
ETHYLESTRENOL
CHEMBL1200623
|
1964 |
|
|
NORTRIPTYLINE
CHEMBL445
|
1964 |
|
|
THIORIDAZINE
CHEMBL479
|
1962 |
|
|
AMITRIPTYLINE
CHEMBL629
|
1961 |
|
|
GLYCOPYRRONIUM
CHEMBL1201335
|
1961 |
|
|
CYPROHEPTADINE
CHEMBL516
|
1961 |
|
|
GLYCOPYRRONIUM BROMIDE
CHEMBL1201027
|
1961 |
|
|
TROPICAMIDE
CHEMBL1200604
|
1960 |
|
|
ATROPINE
CHEMBL517712
|
1960 |
|
|
BIPERIDEN
CHEMBL1101
|
1959 |
Source Header