Muscarinic acetylcholine receptor M1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Muscarinic acetylcholine receptor M1 shows approved-linked disease relevance led by gastrointestinal disease. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11229. Start with gastrointestinal disease, then reuse UniProt P11229 as the stable protein anchor across project notes and exports.
Start with gastrointestinal disease, then reuse UniProt P11229 as the stable protein anchor across project notes and exports.
Muscarinic acetylcholine receptor M1 shows approved-linked disease relevance led by gastrointestinal disease. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with gastrointestinal disease because it currently carries approved-linked support. Linked drugs include ATROPINE, CLIDINIUM BROMIDE, GLYCOPYRRONIUM BROMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMuscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptor M1, mapped to UniProt P11229. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M1 as ChEMBL target CHEMBL216, mapped to UniProt P11229. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Muscarinic acetylcholine receptor M1 is the right protein anchor across sources, using UniProt P11229 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why gastrointestinal disease is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Muscarinic acetylcholine receptor M1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11229 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M1 |
| UniProt Accession | P11229 |
| Component Type | Protein |
| Sequence Length | 460 aa |
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptor M1, mapped to UniProt P11229. Sequence length is 460 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Muscarinic acetylcholine receptor M1 shows approved-linked disease relevance led by gastrointestinal disease. 5 more disease programs remain visible in the same review block.
Start review with gastrointestinal disease because it currently carries approved-linked support. Linked drugs include ATROPINE, CLIDINIUM BROMIDE, GLYCOPYRRONIUM BROMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL112297 | 10.89 | Ki | 0.01288 | Preclinical |
| CHEMBL3545181 | 10.89 | Ki | 0.013 | Approved |
| CHEMBL3084650 | 10.8 | Kd | 0.01585 | Preclinical |
| CHEMBL112297 | 10.52 | Kd | 0.03 | Preclinical |
| CHEMBL4634333 | 10.5 | Ki | 0.03162 | Preclinical |
| CHEMBL3545181 | 10.5 | IC50 | 0.03162 | Approved |
| CHEMBL115078 | 10.4 | Kd | 0.04 | Preclinical |
| CHEMBL2103803 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL12980 | 10.29 | Ki | 0.051 | Preclinical |
| CHEMBL564057 | 10.1 | Ki | 0.08 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 453 | 342 | 6.6 |
| cell-based format | 327 | 1,261 | 6.8 |
| cell membrane format | 13 | 222 | 7.0 |
| assay format | 8 | 128 | 6.8 |
| tissue-based format | 5 | 50 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 276 | 723 | 6.6 |
| assay format | 59 | 161 | 6.3 |
| tissue-based format | 11 | 12 | 6.3 |
| cell membrane format | 3 | 0 | — |
| single protein format | 2 | 1 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 14 | 7.5 |
| single protein format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |