Review anchor
Muscarinic acetylcholine receptor M1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Muscarinic acetylcholine receptor M1
CHEMBL216
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M1 as ChEMBL target CHEMBL216, mapped to UniProt P11229. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL216
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P11229
Muscarinic acetylcholine receptor M1
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Muscarinic acetylcholine receptor M1 matters
Muscarinic acetylcholine receptor M1 is reviewed as Muscarinic acetylcholine receptor M1 (UniProt P11229); Muscarinic acetylcholine receptor M1 shows approved-linked disease relevance led by gastrointestinal disease. 5 more disease programs remain visible in the same review block.; 3 linked drugs keep this evidence frame grounded.; the current evidence base includes 168 approved drugs, 7578 compounds, and 1179 assays, with lead potency reaching pChEMBL 10.9.
Protein context
Muscarinic acetylcholine receptor M1
Muscarinic acetylcholine receptor M1 Sequence length is 460 aa.
Review this target as Muscarinic acetylcholine receptor M1, mapped to UniProt P11229. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P11229
Protein
Disease context
gastrointestinal disease
Muscarinic acetylcholine receptor M1 shows approved-linked disease relevance led by gastrointestinal disease. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include ATROPINE, CLIDINIUM BROMIDE, GLYCOPYRRONIUM BROMIDE.
Start review with gastrointestinal disease because it currently carries approved-linked support. Linked drugs include ATROPINE, CLIDINIUM BROMIDE, GLYCOPYRRONIUM BROMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target record
Approved-linked
3 linked drugs
Activity base
Portfolio and assay base
ChEMBL currently tracks 168 approved drugs, 7578 compounds, and 1179 assays for this target. The dominant activity type is KI. CHEMBL112297 is the current potency anchor at pChEMBL 10.9.
Use CHEMBL112297 as the tractability anchor when discussing potency (pChEMBL 10.9).
Activity source · ChEMBL 36 via Core Engine
168 approved
pChEMBL 10.9
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P11229, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need to see why gastrointestinal disease is currently treated as approved-linked support.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
7578
Total Compounds
1179
Total Assays
168
Approved Drugs
IC50: 1995.0, KI: 2720.0, EC50: 1320.0, KD: 91.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL112297
|
10.9 | Ki | — |
|
|
No preferred name
CHEMBL3545181
|
10.9 | Ki | Approved |
|
|
No preferred name
CHEMBL3084650
|
10.8 | Kd | — |
|
|
No preferred name
CHEMBL112297
|
10.5 | Kd | — |
|
|
No preferred name
CHEMBL4634333
|
10.5 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
XANOMELINE
CHEMBL21536
|
2024 |
|
|
UMECLIDINIUM BROMIDE
CHEMBL523299
|
2013 |
|
|
ACLIDINIUM BROMIDE
CHEMBL551466
|
2012 |
|
|
VEMURAFENIB
CHEMBL1229517
|
2011 |
|
|
LINAGLIPTIN
CHEMBL237500
|
2011 |
|
|
PLERIXAFOR
CHEMBL18442
|
2008 |
|
|
SOLIFENACIN SUCCINATE
CHEMBL1200803
|
2004 |
|
|
TIOTROPIUM BROMIDE
CHEMBL3545181
|
2004 |
|
|
SOLIFENACIN
CHEMBL1734
|
2004 |
|
|
DARIFENACIN
CHEMBL1346
|
2004 |
|
|
TROSPIUM CHLORIDE
CHEMBL3084748
|
2004 |
|
|
DESLORATADINE
CHEMBL1172
|
2001 |
|
|
KETOTIFEN
CHEMBL534
|
1999 |
|
|
TOLTERODINE TARTRATE
CHEMBL1722209
|
1998 |
|
|
TOLTERODINE
CHEMBL1382
|
1998 |
|
|
QUETIAPINE
CHEMBL716
|
1997 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
EBASTINE
CHEMBL305660
|
1990 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
CLOZAPINE
CHEMBL42
|
1989 |
|
|
ASTEMIZOLE
CHEMBL296419
|
1988 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
MITOXANTRONE
CHEMBL58
|
1987 |
|
|
IPRATROPIUM
CHEMBL1621597
|
1986 |
|
|
AMIODARONE
CHEMBL633
|
1985 |
|
|
SULCONAZOLE
CHEMBL1221
|
1985 |
|
|
ECONAZOLE
CHEMBL808
|
1982 |
|
|
CYCLIZINE
CHEMBL648
|
1982 |
|
|
GENTIAN VIOLET
CHEMBL64894
|
1982 |
|
|
DEXCHLORPHENIRAMINE
CHEMBL1201353
|
1981 |
|
|
MAPROTILINE
CHEMBL21731
|
1980 |
|
|
AMOXAPINE
CHEMBL1113
|
1980 |
|
|
SCOPOLAMINE
CHEMBL569713
|
1979 |
|
|
CLEMASTINE
CHEMBL1626
|
1977 |
|
|
TAMOXIFEN
CHEMBL83
|
1977 |
|
|
OXYBUTYNIN
CHEMBL1231
|
1975 |
|
|
MICONAZOLE
CHEMBL91
|
1974 |
|
|
PERHEXILINE
CHEMBL75880
|
1974 |
|
|
PILOCARPINE
CHEMBL550
|
1974 |
|
|
ACETYLCHOLINE CHLORIDE
CHEMBL1184
|
1973 |
|
|
ACETYLCHOLINE
CHEMBL667
|
1973 |
|
|
CARBAMOYLCHOLINE
CHEMBL965
|
1972 |
|
|
DIMENHYDRINATE
CHEMBL1200406
|
1972 |
|
|
CARBACHOL
CHEMBL14
|
1972 |
|
|
DOXEPIN
CHEMBL1628227
|
1969 |
|
|
DIPHENIDOL
CHEMBL936
|
1967 |
|
|
DIPHENIDOL HYDROCHLORIDE
CHEMBL1529
|
1967 |
|
|
NORTRIPTYLINE
CHEMBL445
|
1964 |
Source Header