Muscarinic acetylcholine receptor M4 · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Muscarinic acetylcholine receptor M4 shows late clinical disease relevance led by schizophrenia. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08173. Start with schizophrenia, then reuse UniProt P08173 as the stable protein anchor across project notes and exports.
Start with schizophrenia, then reuse UniProt P08173 as the stable protein anchor across project notes and exports.
Muscarinic acetylcholine receptor M4 shows late clinical disease relevance led by schizophrenia. 2 linked drugs remain visible in the same block.
Start review with schizophrenia because it currently carries late clinical support. Linked drugs include XANOMELINE, XANOMELINE TARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMuscarinic acetylcholine receptor M4
Review this target as Muscarinic acetylcholine receptor M4, mapped to UniProt P08173. Sequence length is 479 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M4 as ChEMBL target CHEMBL1821, mapped to UniProt P08173. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Muscarinic acetylcholine receptor M4 is the right protein anchor across sources, using UniProt P08173 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why schizophrenia is currently framed as late clinical support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Muscarinic acetylcholine receptor M4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08173 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M4 |
| UniProt Accession | P08173 |
| Component Type | Protein |
| Sequence Length | 479 aa |
Muscarinic acetylcholine receptor M4
Review this target as Muscarinic acetylcholine receptor M4, mapped to UniProt P08173. Sequence length is 479 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Muscarinic acetylcholine receptor M4 shows late clinical disease relevance led by schizophrenia.
Start review with schizophrenia because it currently carries late clinical support. Linked drugs include XANOMELINE, XANOMELINE TARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3545181 | 10.4 | IC50 | 0.03981 | Approved |
| CHEMBL5201074 | 10.28 | Kd | 0.052 | Preclinical |
| CHEMBL4860528 | 10.28 | Kd | 0.052 | Preclinical |
| CHEMBL5206565 | 10.28 | Kd | 0.052 | Preclinical |
| CHEMBL5207281 | 10.28 | Kd | 0.052 | Preclinical |
| CHEMBL71124 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL2114068 | 10.05 | Ki | 0.09 | Preclinical |
| CHEMBL1354199 | 10.01 | Ki | 0.098 | Approved |
| CHEMBL517712 | 9.98 | Ki | 0.104 | Approved |
| CHEMBL1910856 | 9.94 | Ki | 0.115 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 221 | 162 | 6.3 |
| cell-based format | 181 | 570 | 6.6 |
| cell membrane format | 8 | 209 | 6.8 |
| assay format | 3 | 399 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 128 | 574 | 6.6 |
| assay format | 44 | 45 | 6.8 |
| single protein format | 5 | 27 | 6.0 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 1 | 5.6 |
| single protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |