Muscarinic acetylcholine receptor M5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P08912. Use UniProt P08912 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08912 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M5
Review this target as Muscarinic acetylcholine receptor M5, mapped to UniProt P08912. Sequence length is 532 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M5 as ChEMBL target CHEMBL2035, mapped to UniProt P08912. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptor M5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08912 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M5 |
| UniProt Accession | P08912 |
| Component Type | Protein |
| Sequence Length | 532 aa |
Muscarinic acetylcholine receptor M5
Review this target as Muscarinic acetylcholine receptor M5, mapped to UniProt P08912. Sequence length is 532 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3545181 | 10.58 | Ki | 0.0266 | Approved |
| CHEMBL3545181 | 10.0 | IC50 | 0.1 | Approved |
| CHEMBL219786 | 9.97 | Ki | 0.1072 | Preclinical |
| CHEMBL2449003 | 9.85 | Ki | 0.14 | Preclinical |
| CHEMBL551466 | 9.8 | IC50 | 0.1585 | Approved |
| CHEMBL1910856 | 9.77 | Ki | 0.169 | Clinical |
| CHEMBL1201027 | 9.7 | IC50 | 0.1995 | Approved |
| CHEMBL376057 | 9.7 | Ki | 0.1995 | Preclinical |
| CHEMBL4860528 | 9.7 | Kd | 0.2 | Preclinical |
| CHEMBL5201074 | 9.7 | Kd | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 175 | 126 | 6.2 |
| cell-based format | 132 | 591 | 6.2 |
| cell membrane format | 6 | 113 | 6.8 |
| assay format | 3 | 29 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 96 | 277 | 6.1 |
| assay format | 30 | 15 | 5.7 |
| single protein format | 5 | 4 | 6.0 |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 2 | 5.7 |
| single protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |