Review anchor
Muscarinic acetylcholine receptor M5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
Evidence Snapshot
Muscarinic acetylcholine receptor M5
CHEMBL2035
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M5 as ChEMBL target CHEMBL2035, mapped to UniProt P08912. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2035
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P08912
Muscarinic acetylcholine receptor M5
UniProt accession via ChEMBL component mapping
As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-14
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Muscarinic acetylcholine receptor M5 matters
Muscarinic acetylcholine receptor M5 is reviewed as Muscarinic acetylcholine receptor M5 (UniProt P08912); the current evidence base includes 138 approved drugs, 3215 compounds, and 458 assays, with lead potency reaching pChEMBL 10.6.
Protein context
Muscarinic acetylcholine receptor M5
Muscarinic acetylcholine receptor M5 Sequence length is 532 aa.
Review this target as Muscarinic acetylcholine receptor M5, mapped to UniProt P08912. Sequence length is 532 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P08912
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 138 approved drugs, 3215 compounds, and 458 assays for this target. The dominant activity type is KI. CHEMBL3545181 is the current potency anchor at pChEMBL 10.6.
Use CHEMBL3545181 as the tractability anchor when discussing potency (pChEMBL 10.6).
Activity source · ChEMBL 36 via Core Engine
138 approved
pChEMBL 10.6
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M5 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P08912, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
3215
Total Compounds
458
Total Assays
138
Approved Drugs
IC50: 1357.0, KI: 1909.0, EC50: 340.0, KD: 4.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL3545181
|
10.6 | Ki | Approved |
|
|
No preferred name
CHEMBL3545181
|
10.0 | IC50 | Approved |
|
|
No preferred name
CHEMBL219786
|
10.0 | Ki | — |
|
|
No preferred name
CHEMBL2449003
|
9.8 | Ki | — |
|
|
No preferred name
CHEMBL551466
|
9.8 | IC50 | Approved |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
XANOMELINE
CHEMBL21536
|
2024 |
|
|
LASMIDITAN
CHEMBL3039520
|
2020 |
|
|
ACLIDINIUM BROMIDE
CHEMBL551466
|
2012 |
|
|
TIOTROPIUM BROMIDE
CHEMBL3545181
|
2004 |
|
|
TROSPIUM CHLORIDE
CHEMBL3084748
|
2004 |
|
|
SOLIFENACIN
CHEMBL1734
|
2004 |
|
|
DARIFENACIN
CHEMBL1346
|
2004 |
|
|
DESLORATADINE
CHEMBL1172
|
2001 |
|
|
KETOTIFEN FUMARATE
CHEMBL1633
|
1999 |
|
|
KETOTIFEN
CHEMBL534
|
1999 |
|
|
TOLTERODINE
CHEMBL1382
|
1998 |
|
|
TOLTERODINE TARTRATE
CHEMBL1722209
|
1998 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
SALMETEROL
CHEMBL1263
|
1994 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
EBASTINE
CHEMBL305660
|
1990 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
CLOZAPINE
CHEMBL42
|
1989 |
|
|
ASTEMIZOLE
CHEMBL296419
|
1988 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
OXYMETAZOLINE
CHEMBL762
|
1986 |
|
|
GENTIAN VIOLET
CHEMBL64894
|
1982 |
|
|
CYCLIZINE
CHEMBL648
|
1982 |
|
|
DEXCHLORPHENIRAMINE
CHEMBL1201353
|
1981 |
|
|
MAPROTILINE
CHEMBL21731
|
1980 |
|
|
AMOXAPINE
CHEMBL1113
|
1980 |
|
|
SCOPOLAMINE
CHEMBL569713
|
1979 |
|
|
CLEMASTINE
CHEMBL1626
|
1977 |
|
|
OXYBUTYNIN
CHEMBL1231
|
1975 |
|
|
PILOCARPINE
CHEMBL550
|
1974 |
|
|
PERHEXILINE
CHEMBL75880
|
1974 |
|
|
ACETYLCHOLINE
CHEMBL667
|
1973 |
|
|
ACETYLCHOLINE CHLORIDE
CHEMBL1184
|
1973 |
|
|
CARBACHOL
CHEMBL14
|
1972 |
|
|
DIMENHYDRINATE
CHEMBL1200406
|
1972 |
|
|
DOXEPIN
CHEMBL1628227
|
1969 |
|
|
DIPHENIDOL
CHEMBL936
|
1967 |
|
|
NORTRIPTYLINE
CHEMBL445
|
1964 |
|
|
THIORIDAZINE
CHEMBL479
|
1962 |
|
|
GLYCOPYRRONIUM BROMIDE
CHEMBL1201027
|
1961 |
|
|
CYPROHEPTADINE
CHEMBL516
|
1961 |
|
|
AMITRIPTYLINE
CHEMBL629
|
1961 |
|
|
TROPICAMIDE
CHEMBL1200604
|
1960 |
|
|
ATROPINE
CHEMBL517712
|
1960 |
|
|
CHLORPROMAZINE
CHEMBL71
|
1957 |
|
|
ORPHENADRINE
CHEMBL900
|
1957 |
|
|
PROCHLORPERAZINE
CHEMBL728
|
1956 |
|
|
PROMAZINE
CHEMBL564
|
1956 |
|
|
BENZTROPINE
CHEMBL1201203
|
1954 |
Source Header