Assay Detail
Binding
CHEMBL1909170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.38 | 9.26 |
| Ki | 871 | 7.00 | 9.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201203 | BENZTROPINE | 4.0 | 2 | 9.88 |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | 4.0 | 2 | 9.49 |
| CHEMBL517712 | ATROPINE | 4.0 | 2 | 9.44 |
| CHEMBL1123 | DICYCLOMINE | 4.0 | 2 | 9.08 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 2 | 9.07 |
| CHEMBL1490 | TRIHEXYPHENIDYL | 4.0 | 2 | 8.87 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 8.77 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 8.61 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 2 | 8.56 |
| CHEMBL2107687 | VALETHAMATE BROMIDE | -1.0 | 2 | 8.56 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 2 | 8.48 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 8.40 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 2 | 8.10 |
| CHEMBL1909073 | PIPERILATE ETHOBROMIDE | — | 2 | 8.08 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 2 | 7.75 |
| CHEMBL395110 | MEPAZINE | 4.0 | 2 | 7.72 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 7.70 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 2 | 7.70 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 2 | 7.66 |
| CHEMBL1319362 | HOMATROPINE HYDROBROMIDE | -1.0 | 2 | 7.50 |
| CHEMBL490 | PAROXETINE | 4.0 | 2 | 7.46 |
| CHEMBL900 | ORPHENADRINE | 4.0 | 2 | 7.44 |
| CHEMBL1172 | DESLORATADINE | 4.0 | 2 | 7.19 |
| CHEMBL1200604 | TROPICAMIDE | 4.0 | 2 | 7.17 |
| CHEMBL936 | DIPHENIDOL | 4.0 | 2 | 7.11 |
| CHEMBL657 | DIPHENHYDRAMINE | 4.0 | 2 | 7.08 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | 7.00 |
| CHEMBL305660 | EBASTINE | 4.0 | 2 | 7.00 |
| CHEMBL1200406 | DIMENHYDRINATE | 4.0 | 2 | 6.96 |
| CHEMBL564 | PROMAZINE | 4.0 | 2 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201203 | BENZTROPINE | Ki | = | 0.131 | nM | 9.88 |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | = | 0.321 | nM | 9.49 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.366 | nM | 9.44 |
| CHEMBL1201203 | BENZTROPINE | IC50 | = | 0.544 | nM | 9.26 |
| CHEMBL1123 | DICYCLOMINE | Ki | = | 0.834 | nM | 9.08 |
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 0.847 | nM | 9.07 |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | = | 1.334 | nM | 8.88 |
| CHEMBL1490 | TRIHEXYPHENIDYL | Ki | = | 1.351 | nM | 8.87 |
| CHEMBL517712 | ATROPINE | IC50 | = | 1.521 | nM | 8.82 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 1.69 | nM | 8.77 |
| CHEMBL42 | CLOZAPINE | Ki | = | 2.474 | nM | 8.61 |
| CHEMBL629 | AMITRIPTYLINE | Ki | = | 2.724 | nM | 8.56 |
| CHEMBL2107687 | VALETHAMATE BROMIDE | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL643 | PROMETHAZINE | Ki | = | 3.321 | nM | 8.48 |
| CHEMBL1123 | DICYCLOMINE | IC50 | = | 3.463 | nM | 8.46 |
| CHEMBL1231 | OXYBUTYNIN | IC50 | = | 3.518 | nM | 8.45 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 3.943 | nM | 8.40 |
| CHEMBL1490 | TRIHEXYPHENIDYL | IC50 | = | 5.608 | nM | 8.25 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 7.019 | nM | 8.15 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | Ki | = | 7.941 | nM | 8.10 |
| CHEMBL1909073 | PIPERILATE ETHOBROMIDE | Ki | = | 8.387 | nM | 8.08 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2107687 | VALETHAMATE BROMIDE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL643 | PROMETHAZINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL516 | CYPROHEPTADINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1628227 | DOXEPIN | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL395110 | MEPAZINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL445 | NORTRIPTYLINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1319362 | HOMATROPINE HYDROBROMIDE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL490 | PAROXETINE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1909073 | PIPERILATE ETHOBROMIDE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL900 | ORPHENADRINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL1172 | DESLORATADINE | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1200604 | TROPICAMIDE | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL936 | DIPHENIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1628227 | DOXEPIN | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL395110 | MEPAZINE | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL657 | DIPHENHYDRAMINE | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL305660 | EBASTINE | Ki | = | 101.2 | nM | 7.00 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL1200406 | DIMENHYDRINATE | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL564 | PROMAZINE | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL1319362 | HOMATROPINE HYDROBROMIDE | IC50 | = | 131.0 | nM | 6.88 |