Cytochrome P450 2C19 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P33261. Use UniProt P33261 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P33261 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2C19
Review this target as Cytochrome P450 2C19, mapped to UniProt P33261. Sequence length is 490 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2C19 as ChEMBL target CHEMBL3622, mapped to UniProt P33261. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cytochrome P450 2C19 is the right protein anchor across sources, using UniProt P33261 as the stable mapping.
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| Preferred Name | Cytochrome P450 2C19 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P33261 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2C19 |
| UniProt Accession | P33261 |
| Component Type | Protein |
| Sequence Length | 490 aa |
Cytochrome P450 2C19
Review this target as Cytochrome P450 2C19, mapped to UniProt P33261. Sequence length is 490 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL91 | 10.7 | IC50 | 0.02 | Approved |
| CHEMBL4593464 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL5561914 | 8.29 | IC50 | 5.1 | Preclinical |
| CHEMBL112532 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL1098230 | 8.07 | IC50 | 8.5 | Preclinical |
| CHEMBL5278512 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL4557596 | 8.04 | IC50 | 9.1 | Preclinical |
| CHEMBL1221 | 7.8 | IC50 | 16.0 | Approved |
| CHEMBL998 | 7.8 | IC50 | 16.0 | Approved |
| CHEMBL104 | 7.8 | IC50 | 16.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,434 | 895 | 5.3 |
| microsome format | 478 | 380 | 5.2 |
| assay format | 385 | 127 | 5.2 |
| cell-based format | 59 | 26 | 4.7 |
| tissue-based format | 43 | 24 | 5.3 |
| cell membrane format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 22 | 117 | 5.2 |
| assay format | 14 | 28 | 5.0 |
| tissue-based format | 8 | 25 | 4.8 |
| microsome format | 3 | 0 | — |
| cell-based format | 1 | 48 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |