Compound Detail
CHEMBL175691
RILPIVIRINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL175691 |
| Name | RILPIVIRINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | YIBOMRUWOWDFLG-ONEGZZNKSA-N |
| Therapeutic | ✓ Yes |
15
Targets
281
Activities
2
Assay Types
30
PK Parameters
20
Publications
10
Known Names
6
Indications
1
Mechanisms
Molecular Properties
366.4
MW (Da)
4.99
ALogP
6
HBA
2
HBD
97.4
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2011 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | Human immunodeficiency virus type 1 reverse transcriptase | ✓ | ✓ |
Indications
HIV Infections HIV Infections Virus Diseases Acquired Immunodeficiency Syndrome Hepatitis C Insulin Resistance
ATC Classification
J05AG05
rilpivirine
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIVIRALS FOR SYSTEMIC USE
Activity Summary
EC50 195 meas. best 10.15
IC50 86 meas. best 9.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 10.15 | 8.7681 | 0.1 | 183 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | EC50 | 9.7 | 9.1 | 0.2 | 7 |
| Human immunodeficiency virus 1 CHEMBL378 | IC50 | 9.48 | 8.515 | 0.3 | 8 |
| Human immunodeficiency virus CHEMBL613758 | IC50 | 9.46 | 9.46 | 0.3 | 1 |
| Unchecked CHEMBL612545 | EC50 | 9.36 | 8.99 | 0.4 | 2 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 9.17 | 7.5076 | 0.7 | 21 |
| Unchecked CHEMBL612545 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 6.47 | 6.47 | 335.0 | 8 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 6.46 | 6.46 | 346.0 | 8 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 6.3 | 6.2089 | 500.0 | 9 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.96 | 5.875 | 1096.0 | 4 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 CHEMBL5393 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 5.66 | 5.66 | 2170.0 | 8 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 5.47 | 5.47 | 3410.0 | 8 |
| ADMET CHEMBL612558 | EC50 | 5.36 | 5.36 | 4400.0 | 1 |
| Human immunodeficiency virus 2 CHEMBL380 | EC50 | 5.28 | 5.28 | 5220.0 | 1 |
| MT2 CHEMBL614184 | EC50 | 5.1 | 5.1 | 8000.0 | 1 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 5.04 | 5.04 | 9110.0 | 8 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 3100.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 8700.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 1400.0 | ng.hr.mL-1 | Cercopithecidae |
| AUC | 44000.0 | ng.hr.mL-1 | Oryctolagus cuniculus |
| AUC | 9800.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 9650.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 23790.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 1230.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 3840.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 15300.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 3540.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 15500.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 117000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 188000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 109000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 20400.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 56800.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 10500.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 70600.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 109000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 148000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 281000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 121000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 265000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 97800.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 219000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 134000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 234000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 8661.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 23200.0 | ng.hr.mL-1 | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine