Cytochrome P450 3A4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P08684. Use UniProt P08684 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08684 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 3A4
Review this target as Cytochrome P450 3A4, mapped to UniProt P08684. Sequence length is 503 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 3A4 as ChEMBL target CHEMBL340, mapped to UniProt P08684. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cytochrome P450 3A4 is the right protein anchor across sources, using UniProt P08684 as the stable mapping.
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| Preferred Name | Cytochrome P450 3A4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08684 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 3A4 |
| UniProt Accession | P08684 |
| Component Type | Protein |
| Sequence Length | 503 aa |
Cytochrome P450 3A4
Review this target as Cytochrome P450 3A4, mapped to UniProt P08684. Sequence length is 503 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1819091 | 10.66 | Ki | 0.022 | Preclinical |
| CHEMBL1819089 | 10.59 | Ki | 0.026 | Preclinical |
| CHEMBL3407558 | 10.3 | IC50 | 0.0503 | Preclinical |
| CHEMBL3125537 | 10.02 | IC50 | 0.0962 | Preclinical |
| CHEMBL3407554 | 9.99 | IC50 | 0.102 | Preclinical |
| CHEMBL1271703 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3407575 | 9.48 | IC50 | 0.33 | Preclinical |
| CHEMBL4593464 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL520419 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL474469 | 9.3 | IC50 | 0.5 | Preclinical |