Compound Detail
CHEMBL1159650
CLOBETASOL PROPIONATE 💊 Approved Drug
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💊 Approved Drug
CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
Basic Information
| ChEMBL ID | CHEMBL1159650 |
| Name | CLOBETASOL PROPIONATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CBGUOGMQLZIXBE-XGQKBEPLSA-N |
| Therapeutic | ✓ Yes |
11
Targets
20
Activities
4
Assay Types
1
PK Parameters
20
Publications
27
Known Names
17
Indications
1
Mechanisms
Molecular Properties
467.0
MW (Da)
4.10
ALogP
5
HBA
1
HBD
80.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1985 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glucocorticoid receptor agonist | AGONIST | Glucocorticoid receptor | ✓ | ✓ |
Indications
Psoriasis Psoriasis Skin Diseases Alopecia Areata Arthritis, Rheumatoid Cataract Dermatitis, Seborrheic Lichen Sclerosus et Atrophicus Pemphigoid, Bullous Vulvar Lichen Sclerosus Colorectal Neoplasms Colorectal Neoplasms Lichen Planus Lichen Planus, Oral Pulmonary Disease, Chronic Obstructive Rectal Neoplasms Dermatitis, Atopic
ATC Classification
D07AD01
clobetasol
Level 1: DERMATOLOGICALS
Level 2: CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
Drug Warnings
Black Box Warning
General Warning
Activity Summary
IC50 14 meas. best 8.84
Ki 3 meas. best 9.18
EC50 2 meas. best 4.6
Kd 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | Ki | 9.18 | 9.18 | 0.7 | 1 |
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.84 | 8.84 | 1.5 | 1 |
| Progesterone receptor CHEMBL1909044 | Ki | 8.82 | 8.82 | 1.5 | 1 |
| Glucocorticoid receptor CHEMBL3368 | IC50 | 8.5 | 8.5 | 3.2 | 1 |
| Progesterone receptor CHEMBL1909044 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Cytochrome P450 3A5 CHEMBL3019 | IC50 | 7.68 | 6.79 | 21.0 | 5 |
| Cytochrome P450 3A5 CHEMBL3019 | Kd | 7.0 | 7.0 | 100.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 6.69 | 6.69 | 206.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 6.1 | 6.1 | 797.0 | 1 |
| Androgen receptor CHEMBL3072 | Ki | 5.6 | 5.6 | 2517.0 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 5.42 | 5.42 | 3775.0 | 1 |
| Bile salt export pump CHEMBL6020 | IC50 | 5.07 | 5.07 | 8500.0 | 2 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Bile salt export pump CHEMBL2073674 | IC50 | 4.46 | 4.46 | 35000.0 | 1 |
| ADMET CHEMBL612558 | EC50 | 4.39 | 4.39 | 41000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 43.0 | nM | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine