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Target Snapshot

CHEMBL1909044 Target Snapshot

Progesterone receptor · SINGLE PROTEIN · Bos taurus

836Compounds
2Assays
76Approved Drugs
1,670.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q690N0. Use UniProt Q690N0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q690N0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Progesterone receptor as ChEMBL target CHEMBL1909044, mapped to UniProt Q690N0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Progesterone receptor
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL1909044
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q690N0
Progesterone receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Progesterone receptor is the right protein anchor across sources, using UniProt Q690N0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProgesterone receptor
UniProt AccessionQ690N0
Component TypeProtein
Sequence Length482 aa

Progesterone receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Progesterone receptor, mapped to UniProt Q690N0. Sequence length is 482 aa.

Mapped IDQ690N0
Review nameProgesterone receptor
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

76
Approved
8
Phase III
6
Phase II
Assay Mix

Activity Type Distribution

IC50835.0
KI835.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1200845 9.92 Ki 0.121 Approved
CHEMBL717 9.53 Ki 0.293 Approved
CHEMBL1276308 9.37 Ki 0.423 Approved
CHEMBL2107797 9.34 Ki 0.458 Approved
CHEMBL110691 9.16 Ki 0.687 Approved
CHEMBL1200845 9.03 IC50 0.93 Approved
CHEMBL1162 8.91 Ki 1.218 Approved
CHEMBL1201139 8.84 Ki 1.439 Approved
CHEMBL1159650 8.82 Ki 1.519 Approved
CHEMBL1062 8.81 Ki 1.549 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
12
5.5
5
6.0
15
6.5
7
7.0
16
7.5
9
8.0
6
8.5
4
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIFEPRISTONE
CHEMBL1276308
Approved 2000
BUDESONIDE
CHEMBL1370
Approved 1994
CLOBETASOL PROPIONATE
CHEMBL1159650
Approved 1985
ETHINYL ESTRADIOL
CHEMBL691
Approved 1982
FLUNISOLIDE
CHEMBL1512
Approved 1981
DIFLORASONE DIACETATE
CHEMBL1200545
Approved 1977
DESOXIMETASONE
CHEMBL1766
Approved 1977
DANAZOL
CHEMBL1479
Approved 1976
PROGESTERONE
CHEMBL103
Approved 1976
HALCINONIDE
CHEMBL1200845
Approved 1974
DIETHYLSTILBESTROL
CHEMBL411
Approved 1973
METHYLTESTOSTERONE
CHEMBL1395
Approved 1973
NORETHINDRONE ACETATE
CHEMBL1201146
Approved 1973
FLUOROMETHOLONE
CHEMBL1200600
Approved 1972
TESTOSTERONE
CHEMBL386630
Approved 1972
FLUOCINONIDE
CHEMBL1501
Approved 1971
MEGESTROL ACETATE
CHEMBL1201139
Approved 1971
NORGESTREL
CHEMBL2107797
Approved 1968
ETHYNODIOL DIACETATE
CHEMBL1200624
Approved 1966
FLURANDRENOLIDE
CHEMBL1201012
Approved 1965
ETHYLESTRENOL
CHEMBL1200623
Approved 1964
FLUOCINOLONE ACETONIDE
CHEMBL989
Approved 1963
NORETHINDRONE
CHEMBL1162
Approved 1962
STANOZOLOL
CHEMBL2079587
Approved 1962
TRIAMCINOLONE ACETONIDE
CHEMBL1504
Approved 1960
SPIRONOLACTONE
CHEMBL1393
Approved 1960
MEDROXYPROGESTERONE ACETATE
CHEMBL717
Approved 1959
CHLORMADINONE ACETATE
CHEMBL110691
Assay Landscape

Assay Landscape

2
Total Assays
48
Tested Compounds
1
Assay Types
Binding — 2 assays, 48 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0
tissue-based format 1 48 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine