Compound Detail

CHEMBL1201012

FLURANDRENOLIDE

💊 Approved Drug

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💊 Approved Drug

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1201012
Name	FLURANDRENOLIDE
Phase	Approved
Structure Type	MOL
InChI Key	POPFMWWJOGLOIF-XWCQMRHXSA-N
Therapeutic	✓ Yes

Known Names

33379 Cordran Cordran sp Fludroxicortida Fludroxicortide Fludroxycortide Flurandrenolide Flurandrenolide component of cordran-n Flurandrenolone Haelan Haelan-c Haelan-x +1 more

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

436.5

MW (Da)

2.50

ALogP

HBA

HBD

93.1

PSA (Å²)

0.69

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	1965
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Topical

USAN Stem	-andr-
USAN Year	1969

Extended Properties

Molecular Formula	C24H33FO6
MW	436.52
Aromatic Rings	0
Heavy Atoms	31
NP-Likeness	2.29

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Glucocorticoid receptor agonist	AGONIST	Glucocorticoid receptor	✓	✓

Indications

Skin Diseases Kidney Failure, Chronic

ATC Classification

D07AC07

fludroxycortide

Level 1: DERMATOLOGICALS

Level 2: CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS

Activity Summary

IC50 3 meas. best 8.35

Ki 2 meas. best 8.69

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucocorticoid receptor CHEMBL2034	Ki	8.69	8.69	2.0	1
Glucocorticoid receptor CHEMBL2034	IC50	8.35	8.35	4.4	1
Progesterone receptor CHEMBL1909044	Ki	7.66	7.66	22.0	1
Progesterone receptor CHEMBL1909044	IC50	6.76	6.76	172.0	1
Bile salt export pump CHEMBL6020	IC50	4.15	4.15	71190.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucocorticoid receptor	Ki	=	2.021	nM	8.69	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	-
Glucocorticoid receptor	IC50	=	4.447	nM	8.35	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	-
Progesterone receptor	Ki	=	22.0	nM	7.66	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	-
Progesterone receptor	IC50	=	172.0	nM	6.76	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	-
Bile salt export pump	IC50	=	71190.0	nM	4.15	Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21...	22961681

Literature References

PubMed	DOI	Target Context	# Activities
22194678	10.1371/journal.pcbi.1002310	Hepatotoxicity	14
-	10.6019/CHEMBL4651402	SARS-CoV-2	2
37468498	10.1038/s41467-023-40064-9	Thromboxane A2 receptor	2
37468498	10.1038/s41467-023-40064-9	Prostaglandin G/H synthase 1	2
37468498	10.1038/s41467-023-40064-9	Alpha-1A adrenergic receptor	2
6827553	10.1021/jm00357a003	Homo sapiens	2
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
37468498	10.1038/s41467-023-40064-9	Muscarinic acetylcholine receptor M1	2
3783574	10.1021/jm00161a001	Homo sapiens	2
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	1
38318365	10.1016/j.isci.2024.108907	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	1
22961681	10.1124/dmd.112.047068	Bile salt export pump	1
37468498	10.1038/s41467-023-40064-9	D(1A) dopamine receptor	1
37468498	10.1038/s41467-023-40064-9	Voltage-gated inwardly rectifying potassium channel KCNH2	1
37468498	10.1038/s41467-023-40064-9	Sodium-dependent dopamine transporter	1
37468498	10.1038/s41467-023-40064-9	Estrogen receptor	1
37468498	10.1038/s41467-023-40064-9	Acetylcholinesterase	1
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B1	1
37468498	10.1038/s41467-023-40064-9	Sodium-dependent serotonin transporter	1
37468498	10.1038/s41467-023-40064-9	Alpha-2A adrenergic receptor	1

Data from ChEMBL 36 via Core Engine