Glucocorticoid receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Glucocorticoid receptor shows approved-linked disease relevance led by asthma. 5 more disease programs remain visible in the same review block. 22 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P04150. Start with asthma, then reuse UniProt P04150 as the stable protein anchor across project notes and exports.
Start with asthma, then reuse UniProt P04150 as the stable protein anchor across project notes and exports.
Glucocorticoid receptor shows approved-linked disease relevance led by asthma. 5 more disease programs remain visible in the same review block. 22 linked drugs remain visible in the same block.
Start review with asthma because it currently carries approved-linked support. Linked drugs include AZD-5423, BECLOMETHASONE DIPROPIONATE, BETAMETHASONE ACETATE, BUDESONIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGlucocorticoid receptor
Review this target as Glucocorticoid receptor, mapped to UniProt P04150. Sequence length is 777 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glucocorticoid receptor as ChEMBL target CHEMBL2034, mapped to UniProt P04150. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Glucocorticoid receptor is the right protein anchor across sources, using UniProt P04150 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why asthma is currently framed as approved-linked support. It currently carries 22 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Glucocorticoid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P04150 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glucocorticoid receptor |
| UniProt Accession | P04150 |
| Component Type | Protein |
| Sequence Length | 777 aa |
Glucocorticoid receptor
Review this target as Glucocorticoid receptor, mapped to UniProt P04150. Sequence length is 777 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Glucocorticoid receptor shows approved-linked disease relevance led by asthma. 5 more disease programs remain visible in the same review block.
Start review with asthma because it currently carries approved-linked support. Linked drugs include AZD-5423, BECLOMETHASONE DIPROPIONATE, BETAMETHASONE ACETATE, BUDESONIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4104286 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL4061359 | 10.54 | IC50 | 0.029 | Preclinical |
| CHEMBL3911831 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL3895181 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL4086388 | 10.49 | IC50 | 0.032 | Preclinical |
| CHEMBL3666813 | 10.43 | IC50 | 0.037 | Preclinical |
| CHEMBL3964460 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL5080959 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL1676 | 10.4 | IC50 | 0.03981 | Approved |
| CHEMBL1473 | 10.4 | IC50 | 0.04 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 425 | 1,729 | 7.7 |
| cell-based format | 386 | 1,191 | 7.4 |
| assay format | 31 | 585 | 7.3 |
| tissue-based format | 6 | 17 | 7.6 |
| subcellular format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 160 | 561 | 7.5 |
| assay format | 103 | 251 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 18 | 52 | 7.2 |
| single protein format | 6 | 15 | 6.0 |
| assay format | 4 | 18 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |