Compound Detail
CHEMBL1395
METHYLTESTOSTERONE 💊 Approved Drug
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💊 Approved Drug
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O
Basic Information
| ChEMBL ID | CHEMBL1395 |
| Name | METHYLTESTOSTERONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GCKMFJBGXUYNAG-HLXURNFRSA-N |
| Therapeutic | ✓ Yes |
4
Targets
8
Activities
3
Assay Types
0
PK Parameters
20
Publications
28
Known Names
4
Indications
1
Mechanisms
Molecular Properties
302.5
MW (Da)
4.27
ALogP
2
HBA
1
HBD
37.3
PSA (Ų)
0.73
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1973 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Androgen Receptor agonist | AGONIST | Androgen receptor | ✓ | ✓ |
Indications
Breast Neoplasms Hypogonadism Orchitis Menopause
ATC Classification
G03BA02
methyltestosterone
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
G03EK01
methyltestosterone
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Activity Summary
IC50 4 meas. best 8.19
Ki 3 meas. best 8.37
Kd 1 meas. best 8.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sex hormone-binding globulin CHEMBL3305 | Kd | 8.43 | 8.43 | 3.7 | 1 |
| Androgen receptor CHEMBL3072 | Ki | 8.37 | 8.37 | 4.3 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 8.19 | 7.995 | 6.4 | 2 |
| Progesterone receptor CHEMBL1909044 | Ki | 7.48 | 7.48 | 33.0 | 1 |
| Progesterone receptor CHEMBL1909044 | IC50 | 6.6 | 6.6 | 251.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 6.08 | 6.08 | 838.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | IC50 | 5.73 | 5.73 | 1843.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine