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Target Snapshot

CHEMBL3072 Target Snapshot

Androgen receptor · SINGLE PROTEIN · Rattus norvegicus

2,769Compounds
255Assays
92Approved Drugs
2,564.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P15207. Use UniProt P15207 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P15207 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Androgen receptor as ChEMBL target CHEMBL3072, mapped to UniProt P15207. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Androgen receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3072
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P15207
Androgen receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Androgen receptor is the right protein anchor across sources, using UniProt P15207 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAndrogen receptor
UniProt AccessionP15207
Component TypeProtein
Sequence Length902 aa

Androgen receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Androgen receptor, mapped to UniProt P15207. Sequence length is 902 aa.

Mapped IDP15207
Review nameAndrogen receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

92
Approved
14
Phase III
22
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC501,424.0
KI1,090.0
EC5048.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3640859 10.7 IC50 0.02 Preclinical
CHEMBL3640847 10.52 IC50 0.03 Preclinical
CHEMBL3640857 10.0 IC50 0.1 Preclinical
CHEMBL3640853 9.7 IC50 0.2 Preclinical
CHEMBL3640855 9.7 IC50 0.2 Preclinical
CHEMBL3640858 9.7 IC50 0.2 Preclinical
CHEMBL484726 9.7 EC50 0.2 Preclinical
CHEMBL27769 9.57 Ki 0.27 Clinical
CHEMBL296323 9.52 Ki 0.302 Preclinical
CHEMBL3640848 9.52 IC50 0.3 Preclinical
Distribution

pChEMBL Value Distribution

68
5.0
92
5.5
131
6.0
104
6.5
80
7.0
96
7.5
70
8.0
47
8.5
27
9.0
9
9.5
pChEMBL
Approved Drugs

Approved Drugs

ENZALUTAMIDE
CHEMBL1082407
Approved 2012
MIFEPRISTONE
CHEMBL1276308
Approved 2000
BICALUTAMIDE
CHEMBL409
Approved 1995
BUDESONIDE
CHEMBL1370
Approved 1994
DORZOLAMIDE
CHEMBL218490
Approved 1994
DANAZOL
CHEMBL1479
Approved 1976
PROGESTERONE
CHEMBL103
Approved 1976
ESTRADIOL
CHEMBL135
Approved 1975
HALCINONIDE
CHEMBL1200845
Approved 1974
METHYLTESTOSTERONE
CHEMBL1395
Approved 1973
NORETHINDRONE ACETATE
CHEMBL1201146
Approved 1973
FLUOROMETHOLONE
CHEMBL1200600
Approved 1972
TESTOSTERONE
CHEMBL386630
Approved 1972
OXYMETHOLONE
CHEMBL1200585
Approved 1972
MEGESTROL ACETATE
CHEMBL1201139
Approved 1971
NORGESTREL
CHEMBL2107797
Approved 1968
ETHYLESTRENOL
CHEMBL1200623
Approved 1964
STANOZOLOL
CHEMBL2079587
Approved 1962
NORETHINDRONE
CHEMBL1162
Approved 1962
ACETOPHENAZINE
CHEMBL1085
Approved 1961
SPIRONOLACTONE
CHEMBL1393
Approved 1960
MEDROXYPROGESTERONE ACETATE
CHEMBL717
Approved 1959
FLUPHENAZINE
CHEMBL726
Approved 1959
CHLORMADINONE ACETATE
CHEMBL110691
Assay Landscape

Assay Landscape

255
Total Assays
587
Tested Compounds
2
Assay Types
Binding — 162 assays, 587 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 90 319 7.2
cell-based format 27 75 6.3
tissue-based format 18 17 7.7
organism-based format 15 9 6.0
assay format 10 113 5.3
cell membrane format 1 53 6.3
subcellular format 1 1 9.5
Functional — 93 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 59 0
tissue-based format 21 0
assay format 9 111 6.2
cell-based format 4 24 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine