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Evidence Snapshot

Androgen receptor

CHEMBL3072 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T00:08:42Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3072
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Androgen receptor as ChEMBL target CHEMBL3072, mapped to UniProt P15207. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Androgen receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3072
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P15207
Androgen receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Androgen receptor matters

As of 2026-09-14

Androgen receptor is reviewed as Androgen receptor (UniProt P15207); the current evidence base includes 92 approved drugs, 2769 compounds, and 255 assays, with lead potency reaching pChEMBL 10.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 92 approved drugs, 2769 compounds, and 255 assays for this target. The dominant activity type is IC50. CHEMBL3640859 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL3640859 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine
92 approved pChEMBL 10.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Androgen receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P15207, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2769
Total Compounds
255
Total Assays
92
Approved Drugs
IC50: 1424.0, KI: 1090.0, EC50: 48.0, KD: 2.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3640859
 10.7 IC50 —
No preferred name
CHEMBL3640847
 10.5 IC50 —
No preferred name
CHEMBL3640857
 10.0 IC50 —
No preferred name
CHEMBL3640853
 9.7 IC50 —
No preferred name
CHEMBL3640855
 9.7 IC50 —

Approved Drugs

Structure Compound First Approval
ENZALUTAMIDE
CHEMBL1082407
 2012
MIFEPRISTONE
CHEMBL1276308
 2000
BICALUTAMIDE
CHEMBL409
 1995
BUDESONIDE
CHEMBL1370
 1994
DORZOLAMIDE
CHEMBL218490
 1994
DANAZOL
CHEMBL1479
 1976
PROGESTERONE
CHEMBL103
 1976
ESTRADIOL
CHEMBL135
 1975
HALCINONIDE
CHEMBL1200845
 1974
METHYLTESTOSTERONE
CHEMBL1395
 1973
NORETHINDRONE ACETATE
CHEMBL1201146
 1973
FLUOROMETHOLONE
CHEMBL1200600
 1972
TESTOSTERONE
CHEMBL386630
 1972
OXYMETHOLONE
CHEMBL1200585
 1972
MEGESTROL ACETATE
CHEMBL1201139
 1971
NORGESTREL
CHEMBL2107797
 1968
ETHYLESTRENOL
CHEMBL1200623
 1964
STANOZOLOL
CHEMBL2079587
 1962
NORETHINDRONE
CHEMBL1162
 1962
ACETOPHENAZINE
CHEMBL1085
 1961
SPIRONOLACTONE
CHEMBL1393
 1960
MEDROXYPROGESTERONE ACETATE
CHEMBL717
 1959
FLUPHENAZINE
CHEMBL726
 1959
CHLORMADINONE ACETATE
CHEMBL110691
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T00:08:42Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3072