Compound Detail
CHEMBL1201146
NORETHINDRONE ACETATE 💊 Approved Drug
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💊 Approved Drug
C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C
Basic Information
| ChEMBL ID | CHEMBL1201146 |
| Name | NORETHINDRONE ACETATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IMONTRJLAWHYGT-ZCPXKWAGSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1162 |
6
Targets
9
Activities
3
Assay Types
0
PK Parameters
20
Publications
22
Known Names
10
Indications
1
Mechanisms
Molecular Properties
340.5
MW (Da)
4.06
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.53
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1973 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Progesterone receptor agonist | AGONIST | Progesterone receptor | ✓ | ✓ |
Indications
Acne Vulgaris Endometriosis Hypogonadism Breast Neoplasms Hemorrhage Menopause Pain Pregnancy Lymphoma Cystic Fibrosis
Activity Summary
IC50 4 meas. best 7.55
Ki 3 meas. best 8.44
EC50 2 meas. best 4.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL1909044 | Ki | 8.44 | 8.44 | 3.6 | 1 |
| Progesterone receptor CHEMBL1909044 | IC50 | 7.55 | 7.55 | 28.0 | 1 |
| Androgen receptor CHEMBL3072 | Ki | 7.15 | 7.15 | 71.0 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 6.97 | 6.97 | 106.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 6.53 | 6.53 | 293.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | IC50 | 6.19 | 6.19 | 646.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 4.77 | 4.77 | 17000.0 | 1 |
| ADMET CHEMBL612558 | EC50 | 4.55 | 4.55 | 28000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 270 |
| - | 10.5281/zenodo.13943903 | ADMET | 65 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 926114 | 10.1021/jm00219a006 | Progesterone receptor | 3 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 20547819 | 10.1128/aac.01777-09 | ADMET | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 20020916 | 10.1080/15376510701857262 | Phospholipidosis | 1 |
Data from ChEMBL 36 via Core Engine