Assay Detail
Binding
CHEMBL1909115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.20 | 8.64 |
| Ki | 871 | 6.37 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | 2.0 | 2 | 8.81 |
| CHEMBL757 | NANDROLONE | 3.0 | 2 | 8.68 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 2 | 8.39 |
| CHEMBL1395 | METHYLTESTOSTERONE | 4.0 | 2 | 8.37 |
| CHEMBL2107797 | NORGESTREL | 4.0 | 2 | 8.37 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 2 | 8.31 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 2 | 8.26 |
| CHEMBL282575 | ESTRADIOL BENZOATE | 2.0 | 2 | 8.16 |
| CHEMBL1479 | DANAZOL | 4.0 | 2 | 8.10 |
| CHEMBL1162 | NORETHINDRONE | 4.0 | 2 | 7.82 |
| CHEMBL2079587 | STANOZOLOL | 4.0 | 2 | 7.82 |
| CHEMBL1200623 | ETHYLESTRENOL | 4.0 | 2 | 7.75 |
| CHEMBL1201139 | MEGESTROL ACETATE | 4.0 | 2 | 7.70 |
| CHEMBL110691 | CHLORMADINONE ACETATE | 4.0 | 2 | 7.68 |
| CHEMBL139835 | CYPROTERONE ACETATE | 3.0 | 2 | 7.51 |
| CHEMBL241694 | ETHISTERONE | 3.0 | 2 | 7.36 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | 4.0 | 2 | 7.15 |
| CHEMBL2103774 | TIBOLONE | 3.0 | 2 | 7.12 |
| CHEMBL1390 | — | — | 2 | 7.04 |
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 2 | 7.04 |
| CHEMBL1200585 | OXYMETHOLONE | 4.0 | 2 | 6.86 |
| CHEMBL103 | PROGESTERONE | 4.0 | 2 | 6.84 |
| CHEMBL135 | ESTRADIOL | 4.0 | 2 | 6.63 |
| CHEMBL1062 | HYDROXYPROGESTERONE | — | 2 | 6.31 |
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 2 | 6.27 |
| CHEMBL1200845 | HALCINONIDE | 4.0 | 2 | 6.23 |
| CHEMBL1200600 | FLUOROMETHOLONE | 4.0 | 2 | 6.07 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 2 | 5.96 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 2 | 5.96 |
| CHEMBL577294 | 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN | 3.0 | 2 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | Ki | = | 1.537 | nM | 8.81 |
| CHEMBL757 | NANDROLONE | Ki | = | 2.099 | nM | 8.68 |
| CHEMBL27769 | STANOLONE | IC50 | = | 2.305 | nM | 8.64 |
| CHEMBL757 | NANDROLONE | IC50 | = | 3.149 | nM | 8.50 |
| CHEMBL386630 | TESTOSTERONE | Ki | = | 4.112 | nM | 8.39 |
| CHEMBL2107797 | NORGESTREL | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL1395 | METHYLTESTOSTERONE | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 4.839 | nM | 8.31 |
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 5.563 | nM | 8.26 |
| CHEMBL386630 | TESTOSTERONE | IC50 | = | 6.169 | nM | 8.21 |
| CHEMBL2107797 | NORGESTREL | IC50 | = | 6.399 | nM | 8.19 |
| CHEMBL1395 | METHYLTESTOSTERONE | IC50 | = | 6.399 | nM | 8.19 |
| CHEMBL282575 | ESTRADIOL BENZOATE | Ki | = | 6.981 | nM | 8.16 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 7.259 | nM | 8.14 |
| CHEMBL1479 | DANAZOL | Ki | = | 7.99 | nM | 8.10 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 8.345 | nM | 8.08 |
| CHEMBL282575 | ESTRADIOL BENZOATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1479 | DANAZOL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2079587 | STANOZOLOL | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1162 | NORETHINDRONE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1200623 | ETHYLESTRENOL | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL110691 | CHLORMADINONE ACETATE | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL2079587 | STANOZOLOL | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1162 | NORETHINDRONE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1200623 | ETHYLESTRENOL | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL139835 | CYPROTERONE ACETATE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL110691 | CHLORMADINONE ACETATE | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL241694 | ETHISTERONE | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL139835 | CYPROTERONE ACETATE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL241694 | ETHISTERONE | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2103774 | TIBOLONE | Ki | = | 75.4 | nM | 7.12 |
| CHEMBL1393 | SPIRONOLACTONE | Ki | = | 90.6 | nM | 7.04 |
| CHEMBL1390 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2103774 | TIBOLONE | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1393 | SPIRONOLACTONE | IC50 | = | 135.9 | nM | 6.87 |
| CHEMBL1390 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL1200585 | OXYMETHOLONE | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL103 | PROGESTERONE | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL1200585 | OXYMETHOLONE | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL135 | ESTRADIOL | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL1062 | HYDROXYPROGESTERONE | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL63560 | (R)-BICALUTAMIDE | Ki | = | 534.0 | nM | 6.27 |
| CHEMBL1200845 | HALCINONIDE | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL1062 | HYDROXYPROGESTERONE | IC50 | = | 739.0 | nM | 6.13 |