Compound Detail
CHEMBL2107797
NORGESTREL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL2107797 |
| Name | NORGESTREL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | WWYNJERNGUHSAO-CULCCENASA-N |
| Therapeutic | ✓ Yes |
6
Targets
12
Activities
3
Assay Types
0
PK Parameters
12
Publications
16
Known Names
2
Indications
1
Mechanisms
Molecular Properties
312.4
MW (Da)
3.88
ALogP
2
HBA
1
HBD
37.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1968 |
| Availability | OTC |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Progesterone receptor agonist | AGONIST | Progesterone receptor | ✓ | ✓ |
Indications
Hemorrhage Endometrial Neoplasms
Activity Summary
IC50 6 meas. best 8.46
Ki 5 meas. best 9.34
Kd 1 meas. best 8.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL1909044 | Ki | 9.34 | 9.34 | 0.5 | 1 |
| Sex hormone-binding globulin CHEMBL3305 | Kd | 8.91 | 8.91 | 1.2 | 1 |
| Progesterone receptor CHEMBL1909044 | IC50 | 8.46 | 8.46 | 3.5 | 1 |
| Androgen receptor CHEMBL3072 | Ki | 8.37 | 8.37 | 4.3 | 1 |
| Androgen receptor CHEMBL3072 | IC50 | 8.19 | 7.96 | 6.4 | 2 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 7.17 | 7.17 | 68.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | IC50 | 6.83 | 6.83 | 149.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 6.22 | 6.22 | 595.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 5.95 | 5.95 | 1119.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.72 | 5.72 | 1922.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.63 | 5.63 | 2359.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 16134935 | 10.1021/jm050403f | Androgen receptor | 1 |
| 18330978 | 10.1021/jm7011485 | Sex hormone-binding globulin | 1 |
| 20553011 | 10.1021/tx1000865 | Hepatotoxicity | 1 |
| 20843939 | 10.1124/dmd.110.035113 | Hepatotoxicity | 1 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 226703 | 10.1021/jm00194a016 | Progesterone receptor | 1 |
| 20876785 | 10.1124/dmd.110.032276 | Liver microsome | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine