Assay Detail
Binding
CHEMBL1909148
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DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.38 | 8.41 |
| Ki | 871 | 6.47 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | 4.0 | 2 | 8.50 |
| CHEMBL452 | CLONAZEPAM | 4.0 | 2 | 8.40 |
| CHEMBL580 | LORAZEPAM | 4.0 | 2 | 8.29 |
| CHEMBL661 | ALPRAZOLAM | 4.0 | 2 | 7.87 |
| CHEMBL12 | DIAZEPAM | 4.0 | 2 | 7.63 |
| CHEMBL13209 | NITRAZEPAM | 3.0 | 2 | 7.35 |
| CHEMBL13341 | NIMETAZEPAM | 2.0 | 2 | 7.07 |
| CHEMBL932 | DIPYRIDAMOLE | 4.0 | 2 | 6.51 |
| CHEMBL1521 | ZALEPLON | 4.0 | 2 | 6.47 |
| CHEMBL56564 | TROPISETRON | 3.0 | 2 | 6.03 |
| CHEMBL451 | CHLORDIAZEPOXIDE | 4.0 | 2 | 5.93 |
| CHEMBL2107797 | NORGESTREL | 4.0 | 2 | 5.72 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 2 | 5.20 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 2 | 5.01 |
| CHEMBL1162 | NORETHINDRONE | 4.0 | 2 | 4.96 |
| CHEMBL98350 | LY-294002 | -1.0 | 2 | 4.76 |
| CHEMBL1479 | DANAZOL | 4.0 | 2 | 4.35 |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
| CHEMBL1200396 | BUPIVACAINE HYDROCHLORIDE | 4.0 | 2 | - |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 2 | - |
| CHEMBL211501 | ANTIMYCIN A | — | 2 | - |
| CHEMBL3084803 | ASTROMICIN | 2.0 | 2 | - |
| CHEMBL1095699 | AZASERINE | 2.0 | 2 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 2 | - |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 2 | - |
| CHEMBL1077 | BROMFENAC | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | Ki | = | 3.151 | nM | 8.50 |
| CHEMBL407 | FLUMAZENIL | IC50 | = | 3.867 | nM | 8.41 |
| CHEMBL452 | CLONAZEPAM | Ki | = | 4.018 | nM | 8.40 |
| CHEMBL452 | CLONAZEPAM | IC50 | = | 4.932 | nM | 8.31 |
| CHEMBL580 | LORAZEPAM | Ki | = | 5.177 | nM | 8.29 |
| CHEMBL580 | LORAZEPAM | IC50 | = | 6.354 | nM | 8.20 |
| CHEMBL661 | ALPRAZOLAM | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL661 | ALPRAZOLAM | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL12 | DIAZEPAM | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL12 | DIAZEPAM | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL13209 | NITRAZEPAM | Ki | = | 44.6 | nM | 7.35 |
| CHEMBL13209 | NITRAZEPAM | IC50 | = | 54.7 | nM | 7.26 |
| CHEMBL13341 | NIMETAZEPAM | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL13341 | NIMETAZEPAM | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL932 | DIPYRIDAMOLE | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL1521 | ZALEPLON | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL1521 | ZALEPLON | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL56564 | TROPISETRON | Ki | = | 926.0 | nM | 6.03 |
| CHEMBL56564 | TROPISETRON | IC50 | = | 1136.0 | nM | 5.95 |
| CHEMBL451 | CHLORDIAZEPOXIDE | Ki | = | 1164.0 | nM | 5.93 |
| CHEMBL451 | CHLORDIAZEPOXIDE | IC50 | = | 1429.0 | nM | 5.84 |
| CHEMBL2107797 | NORGESTREL | Ki | = | 1922.0 | nM | 5.72 |
| CHEMBL2107797 | NORGESTREL | IC50 | = | 2359.0 | nM | 5.63 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 6305.0 | nM | 5.20 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 7738.0 | nM | 5.11 |
| CHEMBL119385 | NEFLAMAPIMOD | Ki | = | 9767.0 | nM | 5.01 |
| CHEMBL1162 | NORETHINDRONE | Ki | = | 10872.0 | nM | 4.96 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 11986.0 | nM | 4.92 |
| CHEMBL1162 | NORETHINDRONE | IC50 | = | 13343.0 | nM | 4.88 |
| CHEMBL98350 | LY-294002 | Ki | = | 17446.0 | nM | 4.76 |
| CHEMBL98350 | LY-294002 | IC50 | = | 21411.0 | nM | 4.67 |
| CHEMBL1479 | DANAZOL | Ki | = | 44266.0 | nM | 4.35 |
| CHEMBL1479 | DANAZOL | IC50 | = | 54326.0 | nM | 4.26 |
| CHEMBL480 | LANSOPRAZOLE | Ki | - | — | - | |
| CHEMBL19215 | METERGOLINE | IC50 | - | — | - | |
| CHEMBL1201193 | LEVOBUPIVACAINE | Ki | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | - | — | - | |
| CHEMBL1201193 | LEVOBUPIVACAINE | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | Ki | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - |