Assay Detail
Binding
CHEMBL1909150
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DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa S3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.97 | 8.84 |
| Ki | 871 | 7.31 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159650 | CLOBETASOL PROPIONATE | 4.0 | 2 | 9.18 |
| CHEMBL1200845 | HALCINONIDE | 4.0 | 2 | 9.13 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 2 | 8.99 |
| CHEMBL1766 | DESOXIMETASONE | 4.0 | 2 | 8.93 |
| CHEMBL989 | FLUOCINOLONE ACETONIDE | 4.0 | 2 | 8.85 |
| CHEMBL1200600 | FLUOROMETHOLONE | 4.0 | 2 | 8.80 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | 4.0 | 2 | 8.70 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 2 | 8.69 |
| CHEMBL1201012 | FLURANDRENOLIDE | 4.0 | 2 | 8.69 |
| CHEMBL1501 | FLUOCINONIDE | 4.0 | 2 | 8.62 |
| CHEMBL1512 | FLUNISOLIDE | 4.0 | 2 | 8.62 |
| CHEMBL1200545 | DIFLORASONE DIACETATE | 4.0 | 2 | 8.54 |
| CHEMBL632 | BETAMETHASONE | 4.0 | 2 | 8.45 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 2 | 8.44 |
| CHEMBL1201207 | BETAMETHASONE PHOSPHORIC ACID | 4.0 | 2 | 8.43 |
| CHEMBL1586 | BECLOMETHASONE | 2.0 | 2 | 8.43 |
| CHEMBL650 | METHYLPREDNISOLONE | 4.0 | 2 | 8.30 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 2 | 8.13 |
| CHEMBL1390 | — | — | 2 | 8.07 |
| CHEMBL1201139 | MEGESTROL ACETATE | 4.0 | 2 | 8.06 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 2 | 8.06 |
| CHEMBL1201010 | FLUDROCORTISONE ACETATE | 4.0 | 2 | 8.03 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 2 | 7.92 |
| CHEMBL110691 | CHLORMADINONE ACETATE | 4.0 | 2 | 7.76 |
| CHEMBL1062 | HYDROXYPROGESTERONE | — | 2 | 7.64 |
| CHEMBL1451 | TRIAMCINOLONE | 4.0 | 2 | 7.58 |
| CHEMBL2107797 | NORGESTREL | 4.0 | 2 | 7.17 |
| CHEMBL241694 | ETHISTERONE | 3.0 | 2 | 7.02 |
| CHEMBL139835 | CYPROTERONE ACETATE | 3.0 | 2 | 6.99 |
| CHEMBL103 | PROGESTERONE | 4.0 | 2 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159650 | CLOBETASOL PROPIONATE | Ki | = | 0.662 | nM | 9.18 |
| CHEMBL1200845 | HALCINONIDE | Ki | = | 0.732 | nM | 9.13 |
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 1.014 | nM | 8.99 |
| CHEMBL1766 | DESOXIMETASONE | Ki | = | 1.169 | nM | 8.93 |
| CHEMBL989 | FLUOCINOLONE ACETONIDE | Ki | = | 1.423 | nM | 8.85 |
| CHEMBL1159650 | CLOBETASOL PROPIONATE | IC50 | = | 1.456 | nM | 8.84 |
| CHEMBL1200600 | FLUOROMETHOLONE | Ki | = | 1.578 | nM | 8.80 |
| CHEMBL1200845 | HALCINONIDE | IC50 | = | 1.611 | nM | 8.79 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | Ki | = | 2.006 | nM | 8.70 |
| CHEMBL1201012 | FLURANDRENOLIDE | Ki | = | 2.021 | nM | 8.69 |
| CHEMBL1370 | BUDESONIDE | Ki | = | 2.034 | nM | 8.69 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 2.232 | nM | 8.65 |
| CHEMBL1512 | FLUNISOLIDE | Ki | = | 2.423 | nM | 8.62 |
| CHEMBL1501 | FLUOCINONIDE | Ki | = | 2.392 | nM | 8.62 |
| CHEMBL1766 | DESOXIMETASONE | IC50 | = | 2.573 | nM | 8.59 |
| CHEMBL1200545 | DIFLORASONE DIACETATE | Ki | = | 2.907 | nM | 8.54 |
| CHEMBL989 | FLUOCINOLONE ACETONIDE | IC50 | = | 3.131 | nM | 8.50 |
| CHEMBL1200600 | FLUOROMETHOLONE | IC50 | = | 3.471 | nM | 8.46 |
| CHEMBL632 | BETAMETHASONE | Ki | = | 3.516 | nM | 8.45 |
| CHEMBL384467 | DEXAMETHASONE | Ki | = | 3.664 | nM | 8.44 |
| CHEMBL1586 | BECLOMETHASONE | Ki | = | 3.743 | nM | 8.43 |
| CHEMBL1201207 | BETAMETHASONE PHOSPHORIC ACID | Ki | = | 3.734 | nM | 8.43 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | IC50 | = | 4.414 | nM | 8.36 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 4.475 | nM | 8.35 |
| CHEMBL1201012 | FLURANDRENOLIDE | IC50 | = | 4.447 | nM | 8.35 |
| CHEMBL650 | METHYLPREDNISOLONE | Ki | = | 5.033 | nM | 8.30 |
| CHEMBL1501 | FLUOCINONIDE | IC50 | = | 5.263 | nM | 8.28 |
| CHEMBL1512 | FLUNISOLIDE | IC50 | = | 5.33 | nM | 8.27 |
| CHEMBL1200545 | DIFLORASONE DIACETATE | IC50 | = | 6.396 | nM | 8.19 |
| CHEMBL131 | PREDNISOLONE | Ki | = | 7.397 | nM | 8.13 |
| CHEMBL632 | BETAMETHASONE | IC50 | = | 7.735 | nM | 8.11 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 8.06 | nM | 8.09 |
| CHEMBL1201207 | BETAMETHASONE PHOSPHORIC ACID | IC50 | = | 8.216 | nM | 8.09 |
| CHEMBL1586 | BECLOMETHASONE | IC50 | = | 8.234 | nM | 8.08 |
| CHEMBL1390 | — | Ki | = | 8.597 | nM | 8.07 |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | = | 8.769 | nM | 8.06 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 8.637 | nM | 8.06 |
| CHEMBL1201010 | FLUDROCORTISONE ACETATE | Ki | = | 9.253 | nM | 8.03 |
| CHEMBL650 | METHYLPREDNISOLONE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL389621 | HYDROCORTISONE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL131 | PREDNISOLONE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL110691 | CHLORMADINONE ACETATE | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1390 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1201010 | FLUDROCORTISONE ACETATE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1062 | HYDROXYPROGESTERONE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1451 | TRIAMCINOLONE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL110691 | CHLORMADINONE ACETATE | IC50 | = | 37.7 | nM | 7.42 |