Compound Detail
CHEMBL1512
FLUNISOLIDE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1
Basic Information
| ChEMBL ID | CHEMBL1512 |
| Name | FLUNISOLIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XSFJVAJPIHIPKU-XWCQMRHXSA-N |
| Therapeutic | ✓ Yes |
2
Targets
4
Activities
2
Assay Types
6
PK Parameters
20
Publications
13
Known Names
5
Indications
1
Mechanisms
Molecular Properties
434.5
MW (Da)
2.27
ALogP
6
HBA
2
HBD
93.1
PSA (Ų)
0.69
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1981 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glucocorticoid receptor agonist | AGONIST | Glucocorticoid receptor | ✓ | ✓ |
Indications
Asthma Lung Diseases, Obstructive Nasal Obstruction Rhinitis Rhinitis, Allergic, Perennial
ATC Classification
R01AD04
flunisolide
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R03BA03
flunisolide
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Activity Summary
IC50 2 meas. best 8.27
Ki 2 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | Ki | 8.62 | 8.62 | 2.4 | 1 |
| Glucocorticoid receptor CHEMBL2034 | IC50 | 8.27 | 8.27 | 5.3 | 1 |
| Progesterone receptor CHEMBL1909044 | Ki | 7.33 | 7.33 | 47.0 | 1 |
| Progesterone receptor CHEMBL1909044 | IC50 | 6.45 | 6.45 | 359.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 8.8 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 12.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 12.9 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 19.0 | mL.min-1.kg-1 | Macaca |
| F | 20.0 | % | Homo sapiens |
| T1/2 | 0.2667 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Ki | = | 2.423 | nM | 8.62 | DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) | - |
| Glucocorticoid receptor | IC50 | = | 5.33 | nM | 8.27 | DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) | - |
| Progesterone receptor | Ki | = | 47.0 | nM | 7.33 | DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) | - |
| Progesterone receptor | IC50 | = | 359.0 | nM | 6.45 | DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) | - |
Literature References
Data from ChEMBL 36 via Core Engine