Assay Detail
Binding
CHEMBL1909191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Uterus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.41 | 9.03 |
| Ki | 871 | 7.29 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200845 | HALCINONIDE | 4.0 | 2 | 9.92 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 2 | 9.53 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 2 | 9.37 |
| CHEMBL2107797 | NORGESTREL | 4.0 | 2 | 9.34 |
| CHEMBL110691 | CHLORMADINONE ACETATE | 4.0 | 2 | 9.16 |
| CHEMBL1162 | NORETHINDRONE | 4.0 | 2 | 8.91 |
| CHEMBL1201139 | MEGESTROL ACETATE | 4.0 | 2 | 8.84 |
| CHEMBL1159650 | CLOBETASOL PROPIONATE | 4.0 | 2 | 8.82 |
| CHEMBL1062 | HYDROXYPROGESTERONE | — | 2 | 8.81 |
| CHEMBL1501 | FLUOCINONIDE | 4.0 | 2 | 8.54 |
| CHEMBL989 | FLUOCINOLONE ACETONIDE | 4.0 | 2 | 8.47 |
| CHEMBL103 | PROGESTERONE | 4.0 | 2 | 8.44 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | 4.0 | 2 | 8.44 |
| CHEMBL139835 | CYPROTERONE ACETATE | 3.0 | 2 | 8.31 |
| CHEMBL241694 | ETHISTERONE | 3.0 | 2 | 8.11 |
| CHEMBL1766 | DESOXIMETASONE | 4.0 | 2 | 7.96 |
| CHEMBL1200545 | DIFLORASONE DIACETATE | 4.0 | 2 | 7.82 |
| CHEMBL1200624 | ETHYNODIOL DIACETATE | 4.0 | 2 | 7.68 |
| CHEMBL1201012 | FLURANDRENOLIDE | 4.0 | 2 | 7.66 |
| CHEMBL757 | NANDROLONE | 3.0 | 2 | 7.65 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | 4.0 | 2 | 7.64 |
| CHEMBL1200623 | ETHYLESTRENOL | 4.0 | 2 | 7.58 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 2 | 7.57 |
| CHEMBL2103774 | TIBOLONE | 3.0 | 2 | 7.54 |
| CHEMBL1395 | METHYLTESTOSTERONE | 4.0 | 2 | 7.48 |
| CHEMBL1479 | DANAZOL | 4.0 | 2 | 7.47 |
| CHEMBL1512 | FLUNISOLIDE | 4.0 | 2 | 7.33 |
| CHEMBL1390 | — | — | 2 | 7.03 |
| CHEMBL1200600 | FLUOROMETHOLONE | 4.0 | 2 | 6.97 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 2 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200845 | HALCINONIDE | Ki | = | 0.121 | nM | 9.92 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 0.293 | nM | 9.53 |
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 0.423 | nM | 9.37 |
| CHEMBL2107797 | NORGESTREL | Ki | = | 0.458 | nM | 9.34 |
| CHEMBL110691 | CHLORMADINONE ACETATE | Ki | = | 0.687 | nM | 9.16 |
| CHEMBL1200845 | HALCINONIDE | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL1162 | NORETHINDRONE | Ki | = | 1.218 | nM | 8.91 |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | = | 1.439 | nM | 8.84 |
| CHEMBL1159650 | CLOBETASOL PROPIONATE | Ki | = | 1.519 | nM | 8.82 |
| CHEMBL1062 | HYDROXYPROGESTERONE | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 2.247 | nM | 8.65 |
| CHEMBL1501 | FLUOCINONIDE | Ki | = | 2.904 | nM | 8.54 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 3.245 | nM | 8.49 |
| CHEMBL989 | FLUOCINOLONE ACETONIDE | Ki | = | 3.346 | nM | 8.47 |
| CHEMBL2107797 | NORGESTREL | IC50 | = | 3.509 | nM | 8.46 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.622 | nM | 8.44 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | Ki | = | 3.615 | nM | 8.44 |
| CHEMBL139835 | CYPROTERONE ACETATE | Ki | = | 4.842 | nM | 8.31 |
| CHEMBL110691 | CHLORMADINONE ACETATE | IC50 | = | 5.265 | nM | 8.28 |
| CHEMBL241694 | ETHISTERONE | Ki | = | 7.75 | nM | 8.11 |
| CHEMBL1162 | NORETHINDRONE | IC50 | = | 9.342 | nM | 8.03 |
| CHEMBL1766 | DESOXIMETASONE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1159650 | CLOBETASOL PROPIONATE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1062 | HYDROXYPROGESTERONE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1200545 | DIFLORASONE DIACETATE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1200624 | ETHYNODIOL DIACETATE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1201012 | FLURANDRENOLIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1501 | FLUOCINONIDE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL757 | NANDROLONE | Ki | = | 22.4 | nM | 7.65 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL989 | FLUOCINOLONE ACETONIDE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1200623 | ETHYLESTRENOL | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1370 | BUDESONIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1201146 | NORETHINDRONE ACETATE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2103774 | TIBOLONE | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL1395 | METHYLTESTOSTERONE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1479 | DANAZOL | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL139835 | CYPROTERONE ACETATE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1512 | FLUNISOLIDE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL241694 | ETHISTERONE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1766 | DESOXIMETASONE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1390 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL1200600 | FLUOROMETHOLONE | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL1200545 | DIFLORASONE DIACETATE | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL691 | ETHINYL ESTRADIOL | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL1200624 | ETHYNODIOL DIACETATE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL27769 | STANOLONE | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL757 | NANDROLONE | IC50 | = | 171.5 | nM | 6.77 |