Progesterone receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-15Progesterone receptor shows approved-linked disease relevance led by endometriosis. 5 more disease programs remain visible in the same review block. 10 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P06401. Start with endometriosis, then reuse UniProt P06401 as the stable protein anchor across project notes and exports.
Start with endometriosis, then reuse UniProt P06401 as the stable protein anchor across project notes and exports.
Progesterone receptor shows approved-linked disease relevance led by endometriosis. 5 more disease programs remain visible in the same review block. 10 linked drugs remain visible in the same block.
Start review with endometriosis because it currently carries approved-linked support. Linked drugs include ASOPRISNIL, CYPROTERONE ACETATE, DANAZOL, LEVONORGESTREL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProgesterone receptor
Review this target as Progesterone receptor, mapped to UniProt P06401. Sequence length is 933 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Progesterone receptor as ChEMBL target CHEMBL208, mapped to UniProt P06401. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Progesterone receptor is the right protein anchor across sources, using UniProt P06401 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why endometriosis is currently framed as approved-linked support. It currently carries 10 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Progesterone receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P06401 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Progesterone receptor |
| UniProt Accession | P06401 |
| Component Type | Protein |
| Sequence Length | 933 aa |
Progesterone receptor
Review this target as Progesterone receptor, mapped to UniProt P06401. Sequence length is 933 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Progesterone receptor shows approved-linked disease relevance led by endometriosis. 5 more disease programs remain visible in the same review block.
Start review with endometriosis because it currently carries approved-linked support. Linked drugs include ASOPRISNIL, CYPROTERONE ACETATE, DANAZOL, LEVONORGESTREL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL556891 | 10.7 | EC50 | 0.02 | Preclinical |
| CHEMBL557293 | 10.7 | EC50 | 0.02 | Preclinical |
| CHEMBL1276308 | 10.68 | IC50 | 0.021 | Approved |
| CHEMBL490088 | 10.6 | IC50 | 0.025 | Preclinical |
| CHEMBL556892 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL562509 | 10.3 | EC50 | 0.05 | Preclinical |
| CHEMBL455411 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL1608 | 10.14 | IC50 | 0.073 | Preclinical |
| CHEMBL507253 | 10.14 | IC50 | 0.073 | Preclinical |
| CHEMBL1161 | 10.1 | Kd | 0.08 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 224 | 902 | 7.1 |
| cell-based format | 153 | 525 | 6.9 |
| assay format | 7 | 79 | 6.8 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 189 | 889 | 7.5 |
| assay format | 41 | 92 | 7.0 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 23 | 7.0 |
| single protein format | 4 | 4 | 5.7 |