Compound Detail
CHEMBL1389
LEVONORGESTREL 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC
Basic Information
| ChEMBL ID | CHEMBL1389 |
| Name | LEVONORGESTREL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | WWYNJERNGUHSAO-XUDSTZEESA-N |
| Therapeutic | ✓ Yes |
1
Targets
2
Activities
1
Assay Types
5
PK Parameters
20
Publications
30
Known Names
20
Indications
1
Mechanisms
Molecular Properties
312.4
MW (Da)
3.88
ALogP
2
HBA
1
HBD
37.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | OTC |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Progesterone receptor agonist | AGONIST | Progesterone receptor | ✓ | ✓ |
Indications
Menorrhagia Anorexia Nervosa Bone Diseases, Metabolic Dysmenorrhea Endometriosis Hemorrhage Migraine Disorders Adenomyosis Endometrial Neoplasms HIV Infections HIV Infections Ovarian Neoplasms Pain Pregnancy Diabetes Mellitus Diabetes Mellitus, Type 2 Hepatitis B, Chronic Hepatitis C, Chronic Leukemia, Lymphocytic, Chronic, B-Cell Neoplasms
ATC Classification
G03AC03
levonorgestrel
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
G03AD01
levonorgestrel
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Activity Summary
EC50 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | EC50 | 9.0 | 9.0 | 1.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.8 | mL.min-1.kg-1 | Homo sapiens |
| F | 87.0 | % | Homo sapiens |
| Fu | 0.025 | - | Homo sapiens |
| MRT | 14.0 | hr | Homo sapiens |
| T1/2 | 9.4 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | EC50 | = | 1.0 | nM | 9.0 | Agonist activity at human PR-alpha expressed in U2OS cells by PathHunter assay | 35797110 |
| Progesterone receptor | EC50 | = | 1.0 | nM | 9.0 | Agonist activity at human PR-beta expressed in U2OS cells by PathHunter assay | 35797110 |
Literature References
Data from ChEMBL 36 via Core Engine